A critical review on induced totipotent stem cells: Types and methods.
Embryonic stem cells
Epigenetics
Induced totipotent stem cells
Totipotent stem cells
Transcription
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
23
04
2022
revised:
22
06
2022
accepted:
05
07
2022
pubmed:
26
7
2022
medline:
10
8
2022
entrez:
25
7
2022
Statut:
ppublish
Résumé
Totipotent stem cells are cells with the capacity to form an entire embryo. Many attempts have been made to convert other types of cells to totipotent stem cells which we called induced totipotent stem cells. Various aspects of these cells such as transcriptional and epigenetics networks are unique. By taking advantage of these aspects, efficient methods have been provided to induce totipotent stem cells. Although this advancement is significant, many aspects of induction such as the underlying mechanism remain to be elucidated. On the other hand, embryonic stem cells usually are the source of induction which raise important questions regarding if these methods are induction or promotion of 2C intrinsic totipotent cells in ESC culture. Here, we review the latest mouse progress in underling mechanism of induction of totipotent stem cells. In addition, we follow up on the progress of Blastoids derived from totipotent stem cells.
Identifiants
pubmed: 35872523
pii: S1873-5061(22)00206-9
doi: 10.1016/j.scr.2022.102857
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102857Informations de copyright
Copyright © 2022. Published by Elsevier B.V.