The Relationship Between Pediatric Gut Microbiota and SARS-CoV-2 Infection.
COVID-19
SARS-CoV-2
diversity index
dysbiosis
gut microbiota
immunology
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
03
2022
accepted:
14
06
2022
entrez:
25
7
2022
pubmed:
26
7
2022
medline:
27
7
2022
Statut:
epublish
Résumé
This is the first study on gut microbiota (GM) in children affected by coronavirus disease 2019 (COVID-19). Stool samples from 88 patients with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and 95 healthy subjects were collected (admission: 3-7 days, discharge) to study GM profile by 16S rRNA gene sequencing and relationship to disease severity. The study group was divided in COVID-19 (68), Non-COVID-19 (16), and MIS-C (multisystem inflammatory syndrome in children) (4). Correlations among GM ecology, predicted functions, multiple machine learning (ML) models, and inflammatory response were provided for COVID-19 and Non-COVID-19 cohorts. The GM of COVID-19 cohort resulted as dysbiotic, with the lowest α-diversity compared with Non-COVID-19 and CTRLs and by a specific β-diversity. Its profile appeared enriched in
Identifiants
pubmed: 35873161
doi: 10.3389/fcimb.2022.908492
pmc: PMC9304937
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
908492Investigateurs
Francesca Calo Carducci
(FC)
Caterina Cancrini
(C)
Sara Chiurchiù
(S)
Marta Ciofi Degli Atti
(M)
Laura Cursi
(L)
Renato Cutrera
(R)
Carmen D'Amore
(C)
Patrizia D'Argenio
(P)
Maria A De Ioris
(MA)
Maia De Luca
(M)
Andrea Finocchi
(A)
Laura Lancella
(L)
Emma Concetta Manno
(EC)
Elena Morrocchi
(E)
Paola Pansa
(P)
Libera Sessa
(L)
Paola Zangari
(P)
Informations de copyright
Copyright © 2022 Romani, Del Chierico, Macari, Pane, Ristori, Guarrasi, Gardini, Pascucci, Cotugno, Perno, Rossi, Villani, Bernardi, Campana, Palma, Putignani and the CACTUS Study Team.
Déclaration de conflit d'intérêts
Author GM, VG, and SG are employed by GenomeUp SRL, Viale Pasteur, 6, 00144, Rome, Italy. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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