Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo.
Journal
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
ISSN: 1712-9532
Titre abrégé: Can J Infect Dis Med Microbiol
Pays: Egypt
ID NLM: 101226876
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
03
2022
revised:
29
05
2022
accepted:
17
06
2022
entrez:
25
7
2022
pubmed:
26
7
2022
medline:
26
7
2022
Statut:
epublish
Résumé
SARS-CoV-2 infection involves the phase of viral replication and inflammatory response predicting the severity of COVID-19. The aim of the study was to analyze the association between IL-6 and hematological and inflammatory parameters and outcomes of patients with COVID-19. Plasma interleukin 6 (IL-6) levels and other inflammatory and hematological parameters were analyzed in 86 adult patients diagnosed with SARS-CoV-2 infection in Kosovo. The median age of patients was 61.50 (49.75-67.25) years. Over half of patients were categorised as severe (58%) and had comorbidities (69%) with hypertension being the most common. The overall mortality rate was 4.7%. The distribution of biochemical parameters across disease severity groups was significantly different for C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), white blood cells (WBC), and granulocytes with higher median values in more severe and critically ill patients whereas lower percentage of lymphocytes, monocytes, and platelet count in severe and critically ill patients. IL-6 levels were increased in 63% of patients with significant differences in the distribution across the following groups; age, disease severity, hospitalisation status, pulmonary infiltrates, oxygen therapy, and hypertension status. IL-6 significantly correlated with CRP, LDH, CK, ESR, and percentages of granulocytes. IL-6 and other inflammatory and hematological parameters were strongly associated with disease severity and may predict the outcome of the SARS-CoV-2 infection.
Identifiants
pubmed: 35873360
doi: 10.1155/2022/4461647
pmc: PMC9298187
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4461647Informations de copyright
Copyright © 2022 Hatixhe Latifi-Pupovci et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this article.
Références
Blood. 1997 Oct 1;90(7):2583-90
pubmed: 9326224
J Card Surg. 2020 Jun;35(6):1298-1301
pubmed: 32442347
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Int Immunol. 2010 May;22(5):347-52
pubmed: 20410258
Front Cell Infect Microbiol. 2022 Feb 25;11:777070
pubmed: 35282595
Signal Transduct Target Ther. 2020 Mar 27;5(1):33
pubmed: 32296069
J Infect. 2020 Jun;80(6):607-613
pubmed: 32283152
Bone Marrow Transplant. 2021 Mar;56(3):570-580
pubmed: 32943758
J Intern Med. 2020 Sep;288(3):335-344
pubmed: 32352202
BMC Infect Dis. 2020 Nov 23;20(1):869
pubmed: 33225909
Clin Microbiol Infect. 2020 Jun;26(6):767-772
pubmed: 32304745
JAMA. 2020 Aug 25;324(8):782-793
pubmed: 32648899
BMC Infect Dis. 2021 Mar 29;21(1):308
pubmed: 33781216
Clin Exp Med. 2021 May;21(2):167-179
pubmed: 33128197
Int J Antimicrob Agents. 2020 May;55(5):105954
pubmed: 32234467
Pol Arch Intern Med. 2020 Apr 30;130(4):304-309
pubmed: 32231171
Cytokine. 2009 Mar;45(3):190-7
pubmed: 19186073
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
J Leukoc Biol. 2012 Jul;92(1):123-31
pubmed: 22493080
Front Immunol. 2021 Feb 18;12:613422
pubmed: 33679753
Clin Infect Dis. 2020 Nov 19;71(16):2174-2179
pubmed: 32445579
Adv Exp Med Biol. 2021;1318:369-402
pubmed: 33973190
PLoS One. 2021 Jun 29;16(6):e0253894
pubmed: 34185801
J Clin Virol. 2020 Jun;127:104370
pubmed: 32344321
Platelets. 2020 May 18;31(4):490-496
pubmed: 32297540
J Transl Med. 2020 Oct 29;18(1):406
pubmed: 33121497
Clin Immunol. 2020 Jun;215:108448
pubmed: 32353634
Nat Commun. 2020 Oct 2;11(1):4968
pubmed: 33009413
Vector Borne Zoonotic Dis. 2020 Dec;20(12):910-915
pubmed: 33054699
J Clin Invest. 2003 Jun;111(12):1805-12
pubmed: 12813013
Nat Immunol. 2015 May;16(5):448-57
pubmed: 25898198
Allergy. 2021 Feb;76(2):428-455
pubmed: 33185910
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
J Med Virol. 2020 Nov;92(11):2283-2285
pubmed: 32343429
mSphere. 2020 Jul 15;5(4):
pubmed: 32669467
Int J Infect Dis. 2020 Jun;95:332-339
pubmed: 32334118
Allergy. 2021 Mar;76(3):751-765
pubmed: 33128792
J Immunol Res. 2016;2016:8426874
pubmed: 27493973
Infection. 2021 Feb;49(1):15-28
pubmed: 32860214
Cells. 2021 Mar 23;10(3):
pubmed: 33806810
J Med Virol. 2020 Jul;92(7):797-806
pubmed: 32198776