Discovery of JND003 as a New Selective Estrogen-Related Receptor α Agonist Alleviating Nonalcoholic Fatty Liver Disease and Insulin Resistance.

ERRα agonist Estrogen-Related Receptor alpha Fatty acid oxidation Liver-specific Errα knockout mouse Nonalcoholic fatty liver disease

Journal

ACS bio & med chem Au
ISSN: 2694-2437
Titre abrégé: ACS Bio Med Chem Au
Pays: United States
ID NLM: 9918232604406676

Informations de publication

Date de publication:
15 Jun 2022
Historique:
entrez: 25 7 2022
pubmed: 26 7 2022
medline: 26 7 2022
Statut: ppublish

Résumé

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver diseases and is causally linked to hepatic insulin resistance and reduced fatty acid oxidation. Therapeutic treatments targeting both hepatic insulin resistance and lipid oxidative metabolism are considered as feasible strategies to alleviate this disease. Emerging evidence suggests Estrogen-Related Receptor alpha (ERRα), the first orphan nuclear receptor identified, as a master regulator in energy homeostasis by controlling glucose and lipid metabolism. Small molecules improving the functions of ERRα may provide a new option for management of NAFLD. In the present study, by using liver-specific

Identifiants

DOI: 10.1021/acsbiomedchemau.1c00050 PMID: 35874496 PMC: PMC9302452
pubmed: 35874496
doi: 10.1021/acsbiomedchemau.1c00050
pmc: PMC9302452
mid: NIHMS1815584
doi:

Types de publication

Journal Article

Langues

eng

Pagination

282-296

Subventions

Organisme : NIDDK NIH HHS
ID : T32 DK120521
Pays : United States

Références

J Gastrointestin Liver Dis. 2018 Dec;27(4):439-448
pubmed: 30574627
Hepatology. 2006 Feb;43(2 Suppl 1):S99-S112
pubmed: 16447287
Acta Pharmacol Sin. 2015 Jan;36(1):51-61
pubmed: 25500872
Biochem Biophys Res Commun. 2007 Jul 6;358(3):813-8
pubmed: 17512501
FEBS Lett. 2009 Feb 18;583(4):643-7
pubmed: 19171140
Cell. 2006 Aug 25;126(4):789-99
pubmed: 16923397
J Biol Chem. 2006 Dec 29;281(52):39897-906
pubmed: 17079227
Mol Cell Biol. 2003 Nov;23(22):7947-56
pubmed: 14585956
Biochem J. 1998 Jan 15;329 ( Pt 2):265-73
pubmed: 9425108
J Recept Signal Transduct Res. 2010 Aug;30(4):193-205
pubmed: 20497091
Mol Cell Biol. 2005 Dec;25(24):10684-94
pubmed: 16314495
Clin J Gastroenterol. 2015 Feb;8(1):1-9
pubmed: 25575848
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5
pubmed: 15100410
PLoS One. 2013 Nov 06;8(11):e76161
pubmed: 24223115
J Med Chem. 2011 Nov 10;54(21):7729-33
pubmed: 21958216
Nat Med. 2017 Nov;23(11):1298-1308
pubmed: 29035368
Mitochondrion. 2011 Jul;11(4):544-52
pubmed: 21497207
Cell Metab. 2016 Mar 8;23(3):479-91
pubmed: 26777690
J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1:S1-6
pubmed: 17567455
Nat Protoc. 2014 Sep;9(9):2100-22
pubmed: 25101824
Sheng Wu Gong Cheng Xue Bao. 2009 Nov;25(11):1627-32
pubmed: 20222459
J Biol Chem. 2004 Dec 10;279(50):52052-8
pubmed: 15466464
Mol Cell Biol. 1997 Sep;17(9):5400-9
pubmed: 9271417
Curr Protoc Neurosci. 2010 Oct;Chapter 4:Unit 4.21
pubmed: 20938923
SLAS Discov. 2017 Jul;22(6):720-731
pubmed: 28346099
J Biol Chem. 1993 Nov 15;268(32):24114-24
pubmed: 8226958
Endocrinology. 2018 May 1;159(5):2153-2164
pubmed: 29635284
Cell Biol Int. 2013 Nov;37(11):1190-6
pubmed: 23852933
Biomed Pharmacother. 2019 Jan;109:1306-1312
pubmed: 30551380
Biochim Biophys Acta. 2011 Aug;1812(8):1032-40
pubmed: 21172432
J Gastroenterol Hepatol. 2009 May;24(5):830-40
pubmed: 19207680
Am J Pathol. 2021 Jul;191(7):1240-1254
pubmed: 33894178
J Hepatol. 2016 Aug;65(2):425-43
pubmed: 27091791
Science. 2005 Jan 21;307(5708):384-7
pubmed: 15662004
J Recept Signal Transduct Res. 2015;35(6):565-8
pubmed: 26037200
J Biol Chem. 2006 Jan 6;281(1):99-106
pubmed: 16267049
Eur J Med Chem. 2017 Aug 18;136:457-467
pubmed: 28525844
J Med Chem. 2011 Feb 10;54(3):788-808
pubmed: 21218783
Biochem Biophys Res Commun. 2014 Feb 7;444(2):177-81
pubmed: 24457025
Aliment Pharmacol Ther. 2017 Jul;46(2):85-95
pubmed: 28464369
J Med Chem. 2007 Dec 27;50(26):6722-4
pubmed: 18052088
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17975-80
pubmed: 24127579
Molecules. 2016 May 13;21(5):
pubmed: 27187341
Cell Metab. 2013 Apr 2;17(4):586-98
pubmed: 23562079

Auteurs

Liufeng Mao (L)

Scientific Research Center, the First Affiliated Hospital of Guangdong Pharmaceutical University, Nonglinxi Road 19, Guangzhou, Guangdong, 510080, PR China.

Lijie Peng (L)

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China.

Xiaomei Ren (X)

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China.

Yi Chu (Y)

Guangzhou Institutes of Biomedicine and Health, #190 Kaiyuan Avenue, Guangzhou 510530, China.
China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China.

Tao Nie (T)

Guangzhou Institutes of Biomedicine and Health, #190 Kaiyuan Avenue, Guangzhou 510530, China.
China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China.

Wanhua Lin (W)

School of Life Sciences, Guangxi Normal University, Guilin, 541004, China.

Xuemei Zhao (X)

School of Biomedical Sciences, the Chinese University of Hong Kong, Hong Kong SAR.

Andrew Libby (A)

Department of Biochemistry and Molecular & Cellular Biology, Basic Science 353, Georgetown University, 3900 Reservoir Road, Washington, DC 20057, USA.

Yong Xu (Y)

Guangzhou Institutes of Biomedicine and Health, #190 Kaiyuan Avenue, Guangzhou 510530, China.
China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China.

Yu Chang (Y)

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China.

Chong Lei (C)

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China.

Kerry Loomes (K)

School of Biological Sciences and Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand.

Na Wang (N)

Guangzhou Institutes of Biomedicine and Health, #190 Kaiyuan Avenue, Guangzhou 510530, China.
School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.

Jinsong Liu (J)

Guangzhou Institutes of Biomedicine and Health, #190 Kaiyuan Avenue, Guangzhou 510530, China.
School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.

Moshe Levi (M)

Department of Biochemistry and Molecular & Cellular Biology, Basic Science 353, Georgetown University, 3900 Reservoir Road, Washington, DC 20057, USA.

Donghai Wu (D)

Guangzhou Institutes of Biomedicine and Health, #190 Kaiyuan Avenue, Guangzhou 510530, China.
China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China.

Xiaoyan Hui (X)

School of Biomedical Sciences, the Chinese University of Hong Kong, Hong Kong SAR.

Ke Ding (K)

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China.
The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
State Key Laboratory of Bioorganic Chemistry and Natural Products, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 210530, China.

Classifications MeSH