A Barrier to Defend - Models of Pulmonary Barrier to Study Acute Inflammatory Diseases.
2D
3D
ALI
LOAC
PCLS
air-liquid
co-culture
organoid
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
03
2022
accepted:
20
06
2022
entrez:
25
7
2022
pubmed:
26
7
2022
medline:
27
7
2022
Statut:
epublish
Résumé
Pulmonary diseases represent four out of ten most common causes for worldwide mortality. Thus, pulmonary infections with subsequent inflammatory responses represent a major public health concern. The pulmonary barrier is a vulnerable entry site for several stress factors, including pathogens such as viruses, and bacteria, but also environmental factors e.g. toxins, air pollutants, as well as allergens. These pathogens or pathogen-associated molecular pattern and inflammatory agents e.g. damage-associated molecular pattern cause significant disturbances in the pulmonary barrier. The physiological and biological functions, as well as the architecture and homeostatic maintenance of the pulmonary barrier are highly complex. The airway epithelium, denoting the first pulmonary barrier, encompasses cells releasing a plethora of chemokines and cytokines, and is further covered with a mucus layer containing antimicrobial peptides, which are responsible for the pathogen clearance. Submucosal antigen-presenting cells and neutrophilic granulocytes are also involved in the defense mechanisms and counterregulation of pulmonary infections, and thus may directly affect the pulmonary barrier function. The detailed understanding of the pulmonary barrier including its architecture and functions is crucial for the diagnosis, prognosis, and therapeutic treatment strategies of pulmonary diseases. Thus, considering multiple side effects and limited efficacy of current therapeutic treatment strategies in patients with inflammatory diseases make experimental
Identifiants
pubmed: 35874776
doi: 10.3389/fimmu.2022.895100
pmc: PMC9300899
doi:
Substances chimiques
Air Pollutants
0
Antimicrobial Peptides
0
Chemokines
0
Cytokines
0
Types de publication
Systematic Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
895100Informations de copyright
Copyright © 2022 Herminghaus, Kozlov, Szabó, Hantos, Gylstorff, Kuebart, Aghapour, Wissuwa, Walles, Walles, Coldewey and Relja.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Compr Physiol. 2011 Jul;1(3):1233-72
pubmed: 23733641
PLoS One. 2016 Aug 08;11(8):e0160282
pubmed: 27501455
Am J Respir Cell Mol Biol. 2005 Dec;33(6):549-54
pubmed: 16123392
Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):766-75
pubmed: 9309991
Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L379-99
pubmed: 18621912
Lancet. 2020 Aug 1;396(10247):320-332
pubmed: 32682491
Crit Care Med. 2009 Sep;37(9):2604-11
pubmed: 19623041
Semin Immunopathol. 2016 Jul;38(4):461-9
pubmed: 27170185
Physiol Rev. 2003 Apr;83(2):309-36
pubmed: 12663861
Contrib Microbiol. 2007;14:113-125
pubmed: 17684336
Circ Res. 1978 May;42(5):593-7
pubmed: 639181
PLoS One. 2015 Jan 30;10(1):e0117056
pubmed: 25635824
Mol Oncol. 2014 Mar;8(2):351-65
pubmed: 24388494
Inhal Toxicol. 2007 Jun;19(8):657-65
pubmed: 17510838
BMC Cell Biol. 2018 Jun 28;19(1):10
pubmed: 29954317
J Appl Physiol (1985). 1999 Dec;87(6):2362-5
pubmed: 10601190
NPJ Regen Med. 2020 Oct 26;5(1):17
pubmed: 33580031
Int J Toxicol. 2008 Nov;27(6):441-8
pubmed: 19482823
Expert Rev Clin Immunol. 2009 Jan 1;5(1):63-75
pubmed: 19885383
J Appl Physiol (1985). 1989 Dec;67(6):2408-19
pubmed: 2606848
Nat Med. 2012 Aug;18(8):1217-23
pubmed: 22820644
Ann Thorac Surg. 2014 Nov;98(5):1721-9; discussion 1729
pubmed: 25149047
Elife. 2020 Nov 24;9:
pubmed: 33228849
Micromachines (Basel). 2021 May 11;12(5):
pubmed: 34064627
Ther Umsch. 2014 May;71(5):258-61
pubmed: 24794334
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Nature. 2011 Mar 31;471(7340):661-5
pubmed: 21455183
J Appl Physiol (1985). 1994 Jan;76(1):65-71
pubmed: 8175549
PLoS One. 2021 Feb 4;16(2):e0245805
pubmed: 33539409
Exp Toxicol Pathol. 2016 Jan;68(1):77-87
pubmed: 26507834
J Aerosol Med Pulm Drug Deliv. 2010 Aug;23(4):243-52
pubmed: 20073554
Crit Care. 2018 Nov 20;22(1):308
pubmed: 30458880
Wiley Interdiscip Rev Dev Biol. 2021 Nov;10(6):e399
pubmed: 33145915
Pharm Res. 2006 Jul;23(7):1482-90
pubmed: 16779708
Am J Respir Cell Mol Biol. 2020 Jan;62(1):14-22
pubmed: 31513744
ALTEX. 2020 Dec 11;38(2):289-306
pubmed: 33313956
Annu Rev Physiol. 2014;76:431-45
pubmed: 24245941
Eur J Pharm Sci. 2015 Mar 10;69:1-9
pubmed: 25555374
Eur Respir J. 2003 Feb;21(2):232-40
pubmed: 12608435
Cell. 2016 Jun 16;165(7):1586-1597
pubmed: 27315476
PLoS One. 2013;8(2):e55311
pubmed: 23393568
Front Physiol. 2020 Apr 03;11:291
pubmed: 32308629
Curr Protoc Mouse Biol. 2020 Dec;10(4):e85
pubmed: 33217226
J Biomed Opt. 2015 Jun;20(6):066009
pubmed: 26112368
Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L921-L932
pubmed: 30211653
J Appl Physiol (1985). 2003 Apr;94(4):1297-306
pubmed: 12626466
Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L25-31
pubmed: 20971803
Drug Deliv Transl Res. 2017 Apr;7(2):217-227
pubmed: 27549106
Science. 1939 Jul 14;90(2324):43-4
pubmed: 17798138
Respir Res. 2006 Jul 08;7:97
pubmed: 16827942
Cell Stem Cell. 2020 Dec 3;27(6):890-904.e8
pubmed: 33128895
Trends Cell Biol. 2011 Dec;21(12):745-54
pubmed: 22033488
Int J Environ Res Public Health. 2018 May 21;15(5):
pubmed: 29883409
Stem Cells Transl Med. 2021 Jan;10(1):98-114
pubmed: 32949227
Respir Physiol Neurobiol. 2015 Aug 15;215:13-9
pubmed: 25896285
J Appl Physiol. 1969 Mar;26(3):375-7
pubmed: 5773180
Nat Biotechnol. 2014 Aug;32(8):773-85
pubmed: 25093879
J Pharmacol Toxicol Methods. 2007 Jan-Feb;55(1):16-26
pubmed: 16793289
Innate Immun. 2021 Jan;27(1):89-98
pubmed: 33317363
Physiol Rep. 2019 May;7(9):e14085
pubmed: 31054186
J Biol Chem. 2014 Nov 28;289(48):33355-63
pubmed: 25315770
Microcirculation. 2001 Apr;8(2):71-88
pubmed: 11379793
J Cell Biochem. 2019 Apr;120(4):4837-4850
pubmed: 30592322
Nature. 2017 Mar 2;543(7643):118-121
pubmed: 28199303
Sci Rep. 2020 May 12;10(1):7865
pubmed: 32398725
J Clin Invest. 1982 Jun;69(6):1277-85
pubmed: 7085874
Curr Pathobiol Rep. 2016;4:47-57
pubmed: 27340610
IEEE Trans Biomed Eng. 1995 Sep;42(9):860-6
pubmed: 7558060
Nucl Med Biol. 2018 Dec;67:36-42
pubmed: 30388434
Biomolecules. 2015 Apr 15;5(2):472-84
pubmed: 25884116
Nat Commun. 2019 Mar 12;10(1):1178
pubmed: 30862802
J Appl Physiol (1985). 2019 Jul 1;127(1):40-46
pubmed: 31070956
Adv Sci (Weinh). 2020 Dec 21;8(3):2002928
pubmed: 33173719
Cell. 2019 Aug 22;178(5):1205-1221.e17
pubmed: 31442408
Nat Rev Mater. 2021;6(5):402-420
pubmed: 33623712
Am J Respir Crit Care Med. 2016 Feb 15;193(4):396-406
pubmed: 26513710
Am J Physiol. 1995 Dec;269(6 Pt 2):H1955-64
pubmed: 8594904
Shock. 2008 Dec;30(6):623-7
pubmed: 18497712
Am J Respir Cell Mol Biol. 2003 Feb;28(2):218-24
pubmed: 12540489
Front Bioeng Biotechnol. 2020 Aug 21;8:987
pubmed: 32974315
ALTEX. 2017;35(2):211-222
pubmed: 29169185
J Tissue Eng Regen Med. 2017 Apr;11(4):1285-1297
pubmed: 26078119
ALTEX. 2019 Feb 12;36(3):388-402
pubmed: 30753736
J Appl Physiol (1985). 2007 Mar;102(3):859-69
pubmed: 17138833
Respir Physiol. 1978 Feb;32(2):121-40
pubmed: 644146
Physiology (Bethesda). 2017 May;32(3):246-260
pubmed: 28404740
Stem Cells Dev. 2015 Jul 15;24(14):1680-90
pubmed: 25758640
Ann Biomed Eng. 2007 Oct;35(10):1722-38
pubmed: 17558554
J Appl Physiol (1985). 2008 Feb;104(2):338-46
pubmed: 18006870
Pathobiology. 2004;71(6):287-94
pubmed: 15627838
Compr Physiol. 2012 Jul;2(3):1921-35
pubmed: 23723029
Antioxid Redox Signal. 2013 Oct 1;19(10):1085-94
pubmed: 22443458
Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 1):1221-8
pubmed: 7551374
Adv Exp Med Biol. 2019;1176:63-69
pubmed: 31016633
J Biol Chem. 2014 Mar 21;289(12):8194-202
pubmed: 24509853
J Leukoc Biol. 2011 Nov;90(5):883-95
pubmed: 21807741
Int J Mol Sci. 2020 Aug 31;21(17):
pubmed: 32878118
Mol Cell. 2020 Dec 17;80(6):1104-1122.e9
pubmed: 33259812
Sci Rep. 2020 Mar 26;10(1):5499
pubmed: 32218519
Thorax. 2004 Aug;59(8):713-21
pubmed: 15282395
Respir Res. 2019 Jul 19;20(1):162
pubmed: 31324219
mBio. 2019 May 7;10(3):
pubmed: 31064833
J Inflamm Res. 2009;2:1-11
pubmed: 22096348
Innate Immun. 2011 Feb;17(3):245-55
pubmed: 20418262
Am J Respir Crit Care Med. 2020 Jun 15;201(12):1536-1544
pubmed: 32135068
Am J Respir Cell Mol Biol. 2014 May;50(5):876-81
pubmed: 24313705
Toxicol In Vitro. 2019 Oct;60:369-382
pubmed: 31233786
Intensive Care Med. 2020 Dec;46(12):2377-2380
pubmed: 32500178
Nat Rev Immunol. 2014 Feb;14(2):81-93
pubmed: 24445666
J Appl Physiol (1985). 1996 May;80(5):1841-9
pubmed: 8727575
Nat Methods. 2011 Jan;8(1):91-6
pubmed: 21151136
Biomed Res Int. 2013;2013:652632
pubmed: 23484138
Eur J Pharm Biopharm. 2020 Nov;156:121-130
pubmed: 32916267
Eur J Pharm Biopharm. 2011 Apr;77(3):398-406
pubmed: 21056660
Redox Biol. 2017 Oct;13:170-181
pubmed: 28578275
Biomed Opt Express. 2018 Apr 26;9(5):2383-2393
pubmed: 29760995
Biomed Res Int. 2015;2015:573210
pubmed: 26523279
Free Radic Biol Med. 2019 Mar;133:153-161
pubmed: 30217775
Biofabrication. 2018 Oct 30;11(1):015002
pubmed: 30270851
J Clin Invest. 2006 Dec;116(12):3106-8
pubmed: 17143325
J Appl Physiol (1985). 1988 Jun;64(6):2318-23
pubmed: 2457008
Respir Res. 2015 Oct 30;16:134
pubmed: 26517982
J Clin Invest. 2013 Nov;123(11):4950-62
pubmed: 24135142
Nat Biotechnol. 2012 Sep;30(9):876-82
pubmed: 22922672
J Cell Biochem. 2007 Dec 1;102(5):1180-9
pubmed: 17440959
J Physiol. 1997 Jun 1;501 ( Pt 2):375-86
pubmed: 9192309
Crit Care Med. 2012 Mar;40(3):754-61
pubmed: 21963582
Circ Res. 1996 Sep;79(3):560-9
pubmed: 8781489
Respir Res. 2010 Jun 21;11:82
pubmed: 20565957
Annu Rev Pathol. 2010;5:223-52
pubmed: 19824827
J Appl Physiol (1985). 1994 Jul;77(1):463-70
pubmed: 7961270
Front Immunol. 2018 Jul 31;9:1777
pubmed: 30108592
J Clin Invest. 1990 Dec;86(6):1945-53
pubmed: 2254454
Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L112-20
pubmed: 20952494
Pulm Circ. 2019 Oct 31;9(4):2045894019883613
pubmed: 31700608
Angiogenesis. 2021 Feb;24(1):145-157
pubmed: 33058027
Am J Respir Crit Care Med. 1998 Jan;157(1):263-72
pubmed: 9445308
Adv Drug Deliv Rev. 2021 Mar;170:386-395
pubmed: 32971227
Methods Mol Biol. 2006;341:141-54
pubmed: 16799196
Nat Rev Immunol. 2008 Feb;8(2):142-52
pubmed: 18204469
Immun Inflamm Dis. 2017 Jan 18;5(1):45-56
pubmed: 28250924
Nat Rev Microbiol. 2017 Jan;15(1):55-63
pubmed: 27694885
Int J Environ Res Public Health. 2020 Nov 13;17(22):
pubmed: 33202948
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Development. 2017 Mar 15;144(6):986-997
pubmed: 28292845
Lancet. 2020 Jan 18;395(10219):200-211
pubmed: 31954465
Toxicol In Vitro. 2019 Feb;54:58-66
pubmed: 30243732
Polymers (Basel). 2021 Jan 24;13(3):
pubmed: 33498852
J Vasc Res. 2006;43(5):473-81
pubmed: 16926551
Lab Invest. 2004 Jun;84(6):736-52
pubmed: 15077120
Am J Respir Cell Mol Biol. 2013 Aug;49(2):167-79
pubmed: 23526222
Sci Rep. 2020 Aug 3;10(1):13022
pubmed: 32747751
Biomaterials. 2014 Jan;35(2):699-710
pubmed: 24144903
Immunity. 2016 Apr 19;44(4):728-38
pubmed: 27096316
Am J Respir Cell Mol Biol. 2020 Jun;62(6):681-691
pubmed: 31991090
Development. 2018 Mar 8;145(5):
pubmed: 29519889
Int Immunopharmacol. 2017 Jun;47:218-226
pubmed: 28433943
Trends Mol Med. 2017 May;23(5):393-410
pubmed: 28341301
Commun Biol. 2021 Feb 5;4(1):168
pubmed: 33547387
J Immunol. 1990 Mar 15;144(6):2327-33
pubmed: 1968927
Am J Respir Crit Care Med. 2005 Oct 15;172(8):972-9
pubmed: 16040786
Methods Mol Biol. 2012;806:31-42
pubmed: 22057443
Int J Biochem Cell Biol. 2013 Nov;45(11):2568-73
pubmed: 23988571
J Vis Exp. 2020 May 13;(159):
pubmed: 32478724
J Immunol. 1997 Sep 15;159(6):2893-903
pubmed: 9300713
J Appl Physiol (1985). 2004 Jul;97(1):204-12
pubmed: 15020580
J Clin Invest. 1999 Aug;104(4):495-502
pubmed: 10449441
Antioxid Redox Signal. 2014 Mar 1;20(7):1126-67
pubmed: 23991888
Genome Med. 2021 Apr 20;13(1):64
pubmed: 33879239
Int J Pharm. 2003 May 12;257(1-2):161-7
pubmed: 12711171
J Vis Exp. 2020 Jul 21;(161):
pubmed: 32773760
Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L917-23
pubmed: 11943655
Nat Commun. 2014 Jun 02;5:3935
pubmed: 24887553
Semin Immunopathol. 2018 Nov;40(6):555-565
pubmed: 30182191
J Toxicol Environ Health A. 2010;73(16):1113-21
pubmed: 20574913
Elife. 2015 Mar 24;4:
pubmed: 25803487
Am J Respir Cell Mol Biol. 1991 Nov;5(5):493-501
pubmed: 1931078
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1723-30
pubmed: 24706852
J Appl Physiol (1985). 1992 Jan;72(1):168-78
pubmed: 1537711
Front Med (Lausanne). 2015 Aug 07;2:49
pubmed: 26301222
NanoImpact. 2020 Apr;18:
pubmed: 32885098
Appl In Vitro Toxicol. 2018 Jun 1;4(2):91-106
pubmed: 32953944
Pulm Pharmacol Ther. 2020 Aug;63:101939
pubmed: 32861762
Sci Rep. 2015 Jan 22;5:7974
pubmed: 25609567
Eur Respir J. 2019 Mar 28;53(3):
pubmed: 30635296
Toxicol Sci. 2018 Mar 1;162(1):301-308
pubmed: 29182718
Annu Rev Pharmacol Toxicol. 2011;51:267-88
pubmed: 20887196
Science. 2010 Jun 25;328(5986):1662-8
pubmed: 20576885
Blood. 2014 Apr 17;123(16):2573-84
pubmed: 24335230
Am J Respir Cell Mol Biol. 2004 Sep;31(3):373-4
pubmed: 15317683
Front Immunol. 2019 Jun 05;10:1294
pubmed: 31231395
J Clin Invest. 2003 Mar;111(5):691-9
pubmed: 12618523
Biochem Biophys Res Commun. 1992 Nov 30;189(1):47-52
pubmed: 1333196
Biomaterials. 2014 Aug;35(26):7355-62
pubmed: 24912816
ALTEX. 2004;21(1):3-7
pubmed: 14976583
Acta Biomater. 2019 Jun;91:235-247
pubmed: 31004840
Influenza Other Respir Viruses. 2013 Nov;7(6):889-94
pubmed: 23134074
J Clin Invest. 2006 Dec;116(12):3211-9
pubmed: 17143330
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18073-8
pubmed: 20923880
Methods Mol Biol. 2019;1940:297-311
pubmed: 30788834