Gut Microbiota Modulates the Protective Role of Ginsenoside Compound K Against Sodium Valproate-Induced Hepatotoxicity in Rat.
Akkermansia muciniphila
ginsenoside compound K
gut microbiota
hepatotoxicity
sodium valproate
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
05
2022
accepted:
13
06
2022
entrez:
25
7
2022
pubmed:
26
7
2022
medline:
26
7
2022
Statut:
epublish
Résumé
This study aimed to investigate the potential role of gut microbiota in the hepatotoxicity of sodium valproate (SVP) and the protective effect of ginsenoside compound K (G-CK) administration against SVP-induced hepatotoxicity in rats. Measurements of 16S rRNA showed that SVP supplementation led to a 140.749- and 248.900-fold increase in the relative abundance of
Identifiants
pubmed: 35875589
doi: 10.3389/fmicb.2022.936585
pmc: PMC9302921
doi:
Types de publication
Journal Article
Langues
eng
Pagination
936585Informations de copyright
Copyright © 2022 Zhou, Zeng, Liao, Chen and Ouyang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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