Patients with Infections of The Central Nervous System Have Lowered Gut Microbiota Alpha Diversity.
16S rRNA sequencing
encephalitis
gut microbiome
neuroinfection
Journal
Current issues in molecular biology
ISSN: 1467-3045
Titre abrégé: Curr Issues Mol Biol
Pays: Switzerland
ID NLM: 100931761
Informations de publication
Date de publication:
29 Jun 2022
29 Jun 2022
Historique:
received:
27
05
2022
revised:
27
06
2022
accepted:
27
06
2022
entrez:
25
7
2022
pubmed:
26
7
2022
medline:
26
7
2022
Statut:
epublish
Résumé
There are multiple lines of evidence for the existence of communication between the central nervous system (CNS), gut, and intestinal microbiome. Despite extensive analysis conducted on various neurological disorders, the gut microbiome was not yet analyzed in neuroinfections. In the current study, we analyzed the gut microbiome in 47 consecutive patients hospitalized with neuroinfection (26 patients had viral encephalitis/meningitis; 8 patients had bacterial meningitis) and in 20 matched for age and gender health controls. Using the QIIME pipeline, 16S rRNA sequencing and classification into operational taxonomic units (OTUs) were performed on the earliest stool sample available. Bacterial taxa such as
Identifiants
pubmed: 35877424
pii: cimb44070200
doi: 10.3390/cimb44070200
pmc: PMC9318043
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2903-2914Subventions
Organisme : National Science Center
ID : 2017/25/B/NZ6/01463
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