Gametogenesis: Exploring an Endogenous Rejuvenation Program to Understand Cellular Aging and Quality Control.
aging
gametogenesis
life span
meiosis
quality control
rejuvenation
Journal
Annual review of genetics
ISSN: 1545-2948
Titre abrégé: Annu Rev Genet
Pays: United States
ID NLM: 0117605
Informations de publication
Date de publication:
30 11 2022
30 11 2022
Historique:
pubmed:
26
7
2022
medline:
3
12
2022
entrez:
25
7
2022
Statut:
ppublish
Résumé
Gametogenesis is a conserved developmental program whereby a diploid progenitor cell differentiates into haploid gametes, the precursors for sexually reproducing organisms. In addition to ploidy reduction and extensive organelle remodeling, gametogenesis naturally rejuvenates the ensuing gametes, leading to resetting of life span. Excitingly, ectopic expression of the gametogenesis-specific transcription factor Ndt80 is sufficient to extend life span in mitotically dividing budding yeast, suggesting that meiotic rejuvenation pathways can be repurposed outside of their natural context. In this review, we highlight recent studies of gametogenesis that provide emerging insight into natural quality control, organelle remodeling, and rejuvenation strategies that exist within a cell. These include selective inheritance, programmed degradation, and de novo synthesis, all of which are governed by the meiotic gene expression program entailing many forms of noncanonical gene regulation. Finally, we highlight critical questions that remain in the field and provide perspective on the implications of gametogenesis research on human health span.
Identifiants
pubmed: 35878627
doi: 10.1146/annurev-genet-080320-025104
pmc: PMC9712276
mid: NIHMS1845767
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-112Subventions
Organisme : NIA NIH HHS
ID : DP2 AG055946
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG071801
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG071869
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM134886
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM140005
Pays : United States
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