Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
25 Jul 2022
25 Jul 2022
Historique:
received:
16
09
2021
accepted:
21
06
2022
entrez:
25
7
2022
pubmed:
26
7
2022
medline:
26
7
2022
Statut:
epublish
Résumé
Immunization with vesicular stomatitis virus (VSV)-vectored COVID-19 vaccine candidates expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly on expression of the ACE2 receptor at the muscular injection site. Here, we report that such a viral vector vaccine did not induce protective immunity following intramuscular immunization of K18-hACE2 transgenic mice. However, when the viral vector was trans-complemented with the VSV glycoprotein, intramuscular immunization resulted in high titers of spike-specific neutralizing antibodies. The vaccinated animals were fully protected following infection with a lethal dose of SARS-CoV-2-S
Identifiants
pubmed: 35879345
doi: 10.1038/s41541-022-00508-7
pii: 10.1038/s41541-022-00508-7
pmc: PMC9309237
doi:
Types de publication
Journal Article
Langues
eng
Pagination
82Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
ID : 310030_189151
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
ID : 4078P0_198473
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
ID : 31CA30_196062
Informations de copyright
© 2022. The Author(s).
Références
Cell. 2021 Apr 29;184(9):2384-2393.e12
pubmed: 33794143
EMBO Rep. 2022 Apr 5;23(4):e54199
pubmed: 35253970
Int J Legal Med. 2020 Jul;134(4):1275-1284
pubmed: 32500199
PLoS Pathog. 2021 Apr 21;17(4):e1009064
pubmed: 33882114
Nature. 2020 May;581(7807):221-224
pubmed: 32225175
Crit Rev Clin Lab Sci. 2022 Jan;59(1):66-75
pubmed: 34598660
PLoS One. 2017 Nov 20;12(11):e0188251
pubmed: 29155867
Nat Commun. 2021 Jun 30;12(1):4048
pubmed: 34193869
World J Virol. 2016 May 12;5(2):85-6
pubmed: 27175354
MMWR Morb Mortal Wkly Rep. 2022 Feb 11;71(6):206-211
pubmed: 35143464
J Gen Virol. 2010 Nov;91(Pt 11):2782-93
pubmed: 20631091
Nat Commun. 2022 Mar 3;13(1):1152
pubmed: 35241661
Physiol Genomics. 2021 Feb 1;53(2):51-60
pubmed: 33275540
Lancet Respir Med. 2020 Jul;8(7):687-695
pubmed: 32386571
PLoS One. 2011;6(10):e25858
pubmed: 21998709
Lancet. 2020 Aug 29;396(10251):597-598
pubmed: 32818439
N Engl J Med. 2020 Aug 6;383(6):590-592
pubmed: 32402155
Viruses. 2021 Jan 19;13(1):
pubmed: 33477869
Nat Microbiol. 2020 Nov;5(11):1330-1339
pubmed: 32704094
Cell Host Microbe. 2020 Sep 9;28(3):486-496.e6
pubmed: 32738193
N Engl J Med. 2020 Oct 15;383(16):1544-1555
pubmed: 32722908
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
Mol Ther. 2022 May 4;30(5):1850-1868
pubmed: 35189345
Drug Discov Today. 2021 Nov;26(11):2619-2636
pubmed: 34332100
Curr Opin Virol. 2020 Oct;44:169-182
pubmed: 33130500
Front Immunol. 2022 Jan 06;12:788235
pubmed: 35069564
Science. 2020 Sep 18;369(6510):1501-1505
pubmed: 32703906
J Gen Virol. 2005 May;86(Pt 5):1455-1465
pubmed: 15831958
NPJ Vaccines. 2021 Jul 22;6(1):91
pubmed: 34294728
Nature. 2021 Apr;592(7852):122-127
pubmed: 33636719
Virus Res. 2013 Sep;176(1-2):16-32
pubmed: 23796410
Arch Virol. 2022 Feb;167(2):327-344
pubmed: 35089389
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Hum Vaccin Immunother. 2020 Dec 1;16(12):2921-2931
pubmed: 32931361
Vaccine. 2022 Apr 1;40(15):2342-2351
pubmed: 35282925
Sci Adv. 2021 Jul 2;7(27):
pubmed: 34215591
J Bone Joint Surg Am. 2020 Jul 15;102(14):1197-1204
pubmed: 32675661
Front Immunol. 2022 Jan 21;12:821538
pubmed: 35126377
JAMA Cardiol. 2020 Nov 1;5(11):1281-1285
pubmed: 32730555
Sci Transl Med. 2021 Oct 20;13(616):eabj5413
pubmed: 34519517
Cell Host Microbe. 2020 Sep 9;28(3):465-474.e4
pubmed: 32798445
J Virol. 2007 Jan;81(2):813-21
pubmed: 17079315
Vaccine. 2009 Feb 18;27(8):1174-83
pubmed: 19135116
Front Immunol. 2022 Jan 27;13:825256
pubmed: 35154144
J Exp Med. 2002 Aug 5;196(3):303-10
pubmed: 12163559
Nature. 2021 Apr;592(7853):283-289
pubmed: 33524990
Hum Vaccin Immunother. 2019;15(10):2269-2285
pubmed: 31368826
Vaccines (Basel). 2022 Mar 12;10(3):
pubmed: 35335067
Vaccines (Basel). 2020 Jul 15;8(3):
pubmed: 32679691
Nat Med. 2005 Jul;11(7):786-90
pubmed: 15937495
Nat Commun. 2020 Dec 16;11(1):6402
pubmed: 33328475