Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21.

Animals Breast Feeding Female Fibroblast Growth Factors Humans Hypothalamus / metabolism Liver / metabolism Mice Obesity / metabolism Rats

Journal

Nature metabolism

ISSN: 2522-5812

Titre abrégé: Nat Metab

Pays: Germany

ID NLM: 101736592

Informations de publication

Date de publication:
07 2022

Historique:

received: 13 03 2021

accepted: 08 06 2022

entrez: 25 7 2022

pubmed: 26 7 2022

medline: 28 7 2022

Statut: ppublish

Résumé

Early-life determinants are thought to be a major factor in the rapid increase of obesity. However, while maternal nutrition has been extensively studied, the effects of breastfeeding by the infant on the reprogramming of energy balance in childhood and throughout adulthood remain largely unknown. Here we show that delayed weaning in rat pups protects them against diet-induced obesity in adulthood, through enhanced brown adipose tissue thermogenesis and energy expenditure. In-depth metabolic phenotyping in this rat model as well as in transgenic mice reveals that the effects of prolonged suckling are mediated by increased hepatic fibroblast growth factor 21 (FGF21) production and tanycyte-controlled access to the hypothalamus in adulthood. Specifically, FGF21 activates GABA-containing neurons expressing dopamine receptor 2 in the lateral hypothalamic area and zona incerta. Prolonged breastfeeding thus constitutes a protective mechanism against obesity by affecting long-lasting physiological changes in liver-to-hypothalamus communication and hypothalamic metabolic regulation.

Identifiants

DOI: 10.1038/s42255-022-00602-z PMID: 35879461 PMC: PMC9314260

pubmed: 35879461

doi: 10.1038/s42255-022-00602-z

pii: 10.1038/s42255-022-00602-z

pmc: PMC9314260

doi:

Substances chimiques

fibroblast growth factor 21 0

Fibroblast Growth Factors 62031-54-3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

901-917

Commentaires et corrections

Type : CommentIn

Informations de copyright

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