Not breastfeeding and risk of autism spectrum disorders among children: a meta-analysis.
Autism spectrum disorders
Breastfeeding
Child
Meta-analysis
Journal
Clinical and experimental pediatrics
ISSN: 2713-4148
Titre abrégé: Clin Exp Pediatr
Pays: Korea (South)
ID NLM: 101761234
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
22
12
2021
accepted:
06
06
2022
pubmed:
27
7
2022
medline:
27
7
2022
entrez:
26
7
2022
Statut:
ppublish
Résumé
To our knowledge, this is the first meta-analysis of the association of not breastfeeding and the risk of autism spectrum disorder (ASD) based on observational studies. This meta-analysis aimed to evaluate of the association of not breastfeeding and the risk of ASD. Three databases (PubMed, Web of Science, and Scopus) were systematically searched until December 2021. Heterogeneity was determined using the chi-square test and its quantity was measured using the I2 statistic. The Begg line regression test was used to assess publication bias. A random-effects model was used to analyze the data. Seven studies were included in this meta-analysis. The total study population included 3,270 individuals. According to the random-effects model, the estimated odds ratio of the risk of ASD associated with not breastfeeding was 1.81 (95% confidence interval, 1.35-2.27; I2=0%). The results of the included studies were homogeneous. Our findings showed that not breastfeeding is a risk factor for ASD. These results suggest the importance of breastfeeding in decreasing the risk of ASD in children.
Sections du résumé
BACKGROUND
BACKGROUND
To our knowledge, this is the first meta-analysis of the association of not breastfeeding and the risk of autism spectrum disorder (ASD) based on observational studies.
PURPOSE
OBJECTIVE
This meta-analysis aimed to evaluate of the association of not breastfeeding and the risk of ASD.
METHODS
METHODS
Three databases (PubMed, Web of Science, and Scopus) were systematically searched until December 2021. Heterogeneity was determined using the chi-square test and its quantity was measured using the I2 statistic. The Begg line regression test was used to assess publication bias. A random-effects model was used to analyze the data. Seven studies were included in this meta-analysis.
RESULTS
RESULTS
The total study population included 3,270 individuals. According to the random-effects model, the estimated odds ratio of the risk of ASD associated with not breastfeeding was 1.81 (95% confidence interval, 1.35-2.27; I2=0%).
CONCLUSION
CONCLUSIONS
The results of the included studies were homogeneous. Our findings showed that not breastfeeding is a risk factor for ASD. These results suggest the importance of breastfeeding in decreasing the risk of ASD in children.
Identifiants
pubmed: 35879869
pii: cep.2021.01872
doi: 10.3345/cep.2021.01872
pmc: PMC9815942
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28-31Subventions
Organisme : Hamadan University of Medical Sciences
ID : 140011199609
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