Chronology of natural selection in Oceanian genomes.
Biological sciences
Evolutionary biology
Genetics
Genomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
15 Jul 2022
15 Jul 2022
Historique:
received:
15
03
2022
revised:
11
05
2022
accepted:
07
06
2022
entrez:
26
7
2022
pubmed:
27
7
2022
medline:
27
7
2022
Statut:
epublish
Résumé
As human populations left Asia to first settle in Oceania around 50,000 years ago, they entered a territory ecologically separated from the Old World for millions of years. We analyzed genomic data of 239 modern Oceanian individuals to detect and date signals of selection specific to this region. Combining both relative and absolute dating approaches, we identified a strong selection pattern between 52,000 and 54,000 years ago in the genomes of descendants of the first settlers of Sahul. This strikingly corresponds to the dates of initial settlement as inferred from archaeological evidence. Loci under selection during this period, some showing enrichment in Denisovan ancestry, overlap genes involved in the immune response and diet, especially based on plants. Pathogens and natural resources, especially from endemic plants, therefore appear to have acted as strong selective pressures on the genomes of the first settlers of Sahul.
Identifiants
pubmed: 35880026
doi: 10.1016/j.isci.2022.104583
pii: S2589-0042(22)00855-0
pmc: PMC9308150
doi:
Types de publication
Journal Article
Langues
eng
Pagination
104583Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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