Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders.
Exercise
Exercise mimetics
Frailty
Musculoskeletal disorders
Tissue cross-talk
Journal
Current osteoporosis reports
ISSN: 1544-2241
Titre abrégé: Curr Osteoporos Rep
Pays: United States
ID NLM: 101176492
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
accepted:
06
07
2022
pubmed:
27
7
2022
medline:
4
10
2022
entrez:
26
7
2022
Statut:
ppublish
Résumé
The incidence of musculoskeletal disorders affecting bones, joints, and muscles is dramatically increasing in parallel with the increased longevity of the worldwide population, severely impacting on the individual's quality of life and on the healthcare costs. Inactivity and sedentary lifestyle are nowadays considered the main drivers of age-associated musculoskeletal disorders and exercise may counteract such alterations also in other bone- and muscle-centered disorders. This review aims at clarifying the potential use of exercise training to improve musculoskeletal health. Both the skeletal muscle and the bone are involved in a complex crosstalk determining, in part through tissue-specific and inflammatory/immune released factors, the occurrence of musculoskeletal disorders. Exercise is able to modulate the levels of those molecules and several associated molecular pathways. Evidence from preclinical and clinical trials supports the adoption of exercise and the future use of exercise mimicking drugs will optimize the care of individuals with musculoskeletal disorders.
Identifiants
pubmed: 35881303
doi: 10.1007/s11914-022-00739-6
pii: 10.1007/s11914-022-00739-6
pmc: PMC9522759
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
249-259Informations de copyright
© 2022. The Author(s).
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