Effects of Smoking on Optic Nerve Head Microvasculature Density in Glaucoma.
Journal
Journal of glaucoma
ISSN: 1536-481X
Titre abrégé: J Glaucoma
Pays: United States
ID NLM: 9300903
Informations de publication
Date de publication:
01 09 2022
01 09 2022
Historique:
received:
12
05
2022
accepted:
24
06
2022
pubmed:
27
7
2022
medline:
9
9
2022
entrez:
26
7
2022
Statut:
ppublish
Résumé
Decreased superficial whole image capillary density was observed in open angle glaucoma (OAG) patients with high smoking intensity. To investigate the effects of smoking on optic nerve head capillary density measured by optical coherence tomography angiography in patients with OAG. In this retrospective cross-sectional study, perimetric and preperimetric glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study (DIGS) with optical coherence tomography angiography follow-up were included. Univariable and multivariable linear mixed analysis were performed to determine the effects of different variables on the superficial whole image capillary density. A total of 432 eyes of 271 glaucoma patients comprising 63 preperimetric (106 eyes) and 208 perimetric OAG (326 eyes) were included. A history of tobacco consumption was reported in 105 (38.8%). Among smokers, mean (95% confidence interval) smoking intensity was 12.8 (10.2, 15.5) pack-years. After adjusting for age, glaucoma severity and other confounders, each 10 pack-year increase in smoking intensity (95% confidence interval) was associated with -0.54 (-1.06, -0.02) % lower whole image capillary density ( P =0.041). Smoking intensity is associated with reduced optic nerve vessel density in glaucoma.
Identifiants
pubmed: 35882030
doi: 10.1097/IJG.0000000000002081
pii: 00061198-202209000-00002
pmc: PMC9994055
mid: NIHMS1821605
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
710-716Subventions
Organisme : NEI NIH HHS
ID : R01 EY029058
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY023704
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY034148
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026574
Pays : United States
Organisme : NIH HHS
ID : DP5 OD029610
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY011008
Pays : United States
Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure: R.N.W. has received financial support from C: Aerie Pharmaceuticals, Allergan, Equinox, Eyenovia, Nicox, Topcon; F: Heidelberg Engineering, Carl Zeiss Meditec, Konan Medical, Optovue, Centervue, Bausch & Lomb, Topcon; P: Toromedes, Carl Zeiss Meditec, Topcon. The remaining authors declare no conflict of interest.
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