Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
26 07 2022
26 07 2022
Historique:
received:
24
05
2022
accepted:
01
07
2022
revised:
28
06
2022
entrez:
26
7
2022
pubmed:
27
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the 'normativeness' of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.
Identifiants
pubmed: 35882855
doi: 10.1038/s41398-022-02057-y
pii: 10.1038/s41398-022-02057-y
pmc: PMC9325730
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
297Subventions
Organisme : NIH HHS
ID : R01AG058854
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH107558
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH113619
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002387
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH112774
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH117434
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113533
Pays : United States
Organisme : NIH HHS
ID : P41EB015922
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH115332
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH116147
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Investigateurs
Camilo de la Fuente-Sandoval
(C)
Sabrina Catalano
(S)
Daniela Hubl
(D)
Jason Schiffman
(J)
Enea D Venegoni
(ED)
Christine I Hooker
(CI)
Paul E Rasser
(PE)
Wenche Ten Velden Hegelstad
(WTV)
Franz Resch
(F)
Imke L J Lemmers-Jansen
(ILJ)
G Paul Amminger
(GP)
Xiaogang Chen
(X)
Kang Ik K Cho
(KIK)
Birte Yding Glenthøj
(BY)
Lieuwe de Haan
(L)
Matthew A Harris
(MA)
Wu Jeong Hwang
(WJ)
Pablo León-Ortiz
(P)
Xiaoqian Ma
(X)
Patrick McGorry
(P)
Ricardo Mora-Durán
(R)
Masafumi Mizuno
(M)
Merete Nordentoft
(M)
Lijun Ouyang
(L)
Jose C Pariente
(JC)
Francisco Reyes-Madrigal
(F)
Mikkel E Sørensen
(ME)
Dennis Velakoulis
(D)
Sophia Vinogradov
(S)
Christina Wenneberg
(C)
Hidenori Yamasue
(H)
Liu Yuan
(L)
Alison R Yung
(AR)
Informations de copyright
© 2022. The Author(s).
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