Exercise-induced FNDC5/irisin protects nucleus pulposus cells against senescence and apoptosis by activating autophagy.

Animals Apoptosis Autophagy Fibronectins / metabolism Intervertebral Disc Degeneration / metabolism Mice Nucleus Pulposus / metabolism Rats Swimming Transcription Factors / metabolism

Journal

Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880

Informations de publication

Date de publication:
07 2022
Historique:
received: 16 02 2022
accepted: 09 05 2022
revised: 06 05 2022
pubmed: 27 7 2022
medline: 10 8 2022
entrez: 26 7 2022
Statut: ppublish

Résumé

Intervertebral disc degeneration (IVDD) is a major cause of low back pain (LBP), and excessive senescence and apoptosis of nucleus pulposus (NP) cells are major pathological changes in IVDD. Physical exercise could effectively delay the process of intervertebral disc degeneration; however, its mechanism is still largely unknown. Irisin is an exercise-induced myokine released upon cleavage of the membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5), and its levels increase after physical exercise. Here, we show that after physical exercise, FNDC5/irisin levels increase in the circulation and NP, senescence and apoptosis are reduced, autophagy is activated in NP tissue, and the progression of IVDD is delayed. Conversely, after knocking out FNDC5, the benefits of physical exercise are compromised. Moreover, the overexpression of FNDC5 in NP tissue effectively alleviated the degeneration of the intervertebral disc (IVD) in rats. By showing that FNDC5/irisin is an important mediator of the beneficial effects of physical exercise in the IVDD model, the study proposes FNDC5/irisin as a novel agent capable of activating autophagy and protecting NP from senescence and apoptosis.

Identifiants

DOI: 10.1038/s12276-022-00811-2 PMID: 35882943 PMC: PMC9355987
pubmed: 35882943
doi: 10.1038/s12276-022-00811-2
pii: 10.1038/s12276-022-00811-2
pmc: PMC9355987
doi:

Substances chimiques

FNDC5 protein, mouse 0
FNDC5 protein, rat 0
Fibronectins 0
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1038-1048

Informations de copyright

© 2022. The Author(s).

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Auteurs

Wenxian Zhou (W)

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.
Zhejiang Provincial Key Laboratory of Orthopedics, 325000, Wenzhou, Zhejiang Province, China.
The Second School of Medicine, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.

Yifeng Shi (Y)

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.
Zhejiang Provincial Key Laboratory of Orthopedics, 325000, Wenzhou, Zhejiang Province, China.
The Second School of Medicine, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.

Hui Wang (H)

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.
Zhejiang Provincial Key Laboratory of Orthopedics, 325000, Wenzhou, Zhejiang Province, China.
The Second School of Medicine, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.

Linjie Chen (L)

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.
Zhejiang Provincial Key Laboratory of Orthopedics, 325000, Wenzhou, Zhejiang Province, China.
The Second School of Medicine, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.

Caiyu Yu (C)

The School of Ophthalmology and Optometry, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.

Xufei Zhang (X)

Laboratory Animal Center, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.

Lei Yang (L)

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.
Zhejiang Provincial Key Laboratory of Orthopedics, 325000, Wenzhou, Zhejiang Province, China.
The Second School of Medicine, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China.

Xiaolei Zhang (X)

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China. zhangxiaolei@wmu.edu.cn.
Zhejiang Provincial Key Laboratory of Orthopedics, 325000, Wenzhou, Zhejiang Province, China. zhangxiaolei@wmu.edu.cn.
The Second School of Medicine, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China. zhangxiaolei@wmu.edu.cn.
ORCID: 0000-0003-0117-7599

Aimin Wu (A)

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China. aiminwu@wmu.edu.cn.
Zhejiang Provincial Key Laboratory of Orthopedics, 325000, Wenzhou, Zhejiang Province, China. aiminwu@wmu.edu.cn.
The Second School of Medicine, Wenzhou Medical University, 325000, Wenzhou, Zhejiang Province, China. aiminwu@wmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Fibronectines › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Maladies du rachis › Dégénérescence de disque intervertébral › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Nucleus pulposus › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Loisir › Sports › Sports nautiques › Natation › Exercise-induced FNDC5/irisin protects nucleus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Exercise-induced FNDC5/irisin protects nucleus...