Cancer-associated fibroblasts in the single-cell era.
Journal
Nature cancer
ISSN: 2662-1347
Titre abrégé: Nat Cancer
Pays: England
ID NLM: 101761119
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
09
09
2021
accepted:
14
06
2022
entrez:
26
7
2022
pubmed:
27
7
2022
medline:
29
7
2022
Statut:
ppublish
Résumé
Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes, origins and functions and consist of distinct subpopulations. Recent progress in single-cell RNA-sequencing technologies has enabled detailed characterization of the complexity and heterogeneity of CAF subpopulations in multiple tumor types. In this Review, we discuss the current understanding of CAF subsets and functions as elucidated by single-cell technologies, their functional plasticity, and their emergent shared and organ-specific features that could potentially be harnessed to design better therapeutic strategies for cancer.
Identifiants
pubmed: 35883004
doi: 10.1038/s43018-022-00411-z
pii: 10.1038/s43018-022-00411-z
pmc: PMC7613625
mid: EMS145989
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
793-807Subventions
Organisme : Worldwide Cancer Research
ID : 20-0169
Pays : United Kingdom
Informations de copyright
© 2022. Springer Nature America, Inc.
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