Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma.
Nasopharyngeal carcinoma
PI3K/AKT/mTOR
miRNAs
Journal
Biomarker research
ISSN: 2050-7771
Titre abrégé: Biomark Res
Pays: England
ID NLM: 101607860
Informations de publication
Date de publication:
26 Jul 2022
26 Jul 2022
Historique:
received:
16
04
2022
accepted:
06
07
2022
entrez:
26
7
2022
pubmed:
27
7
2022
medline:
27
7
2022
Statut:
epublish
Résumé
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumours of the head and neck in Southeast Asia and southern China. The Phosphatidylinositol 3-kinase/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway is involved in processes related to tumour initiation/progression, such as proliferation, apoptosis, metastasis, and drug resistance, and is closely related to the clinicopathological features of NPC. In addition, key genes involved in the PI3K/AKT/mTOR signalling pathway undergo many changes in NPC. More interestingly, a growing body of evidence suggests an interaction between this signalling pathway and microRNAs (miRNAs), a class of small noncoding RNAs. Therefore, in this review, we discuss the interactions between key components of the PI3K/AKT/mTOR signalling pathway and various miRNAs and their importance in NPC pathology and explore potential diagnostic biomarkers and therapeutic targets.
Identifiants
pubmed: 35883139
doi: 10.1186/s40364-022-00397-x
pii: 10.1186/s40364-022-00397-x
pmc: PMC9327212
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
52Informations de copyright
© 2022. The Author(s).
Références
Curr Genomics. 2010 Nov;11(7):537-61
pubmed: 21532838
J Pathol. 2022 Apr;256(4):402-413
pubmed: 34919276
Clin Cancer Res. 2016 Apr 15;22(8):2009-19
pubmed: 26589432
Anticancer Drugs. 2020 Oct;31(9):932-941
pubmed: 32282369
World J Surg Oncol. 2020 Feb 3;18(1):29
pubmed: 32013999
Mol Cell Biol. 2004 Jan;24(1):200-16
pubmed: 14673156
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9
pubmed: 16166262
Pharmacol Ther. 2014 May;142(2):164-75
pubmed: 24333502
Int J Mol Sci. 2021 Jun 30;22(13):
pubmed: 34209172
Oncogene. 2015 Apr 23;34(17):2156-66
pubmed: 25347742
Life Sci. 2020 Aug 1;254:117672
pubmed: 32304760
Cell Death Dis. 2020 Jul 2;11(7):509
pubmed: 32641685
Cell Death Dis. 2018 Mar 12;9(3):393
pubmed: 29531214
Med Sci Monit Basic Res. 2020 May 25;26:e923431
pubmed: 32448862
Nat Rev Immunol. 2002 Aug;2(8):569-79
pubmed: 12154376
Genes (Basel). 2020 Aug 04;11(8):
pubmed: 32759652
Cell Mol Biol Lett. 2020 Nov 3;25(1):49
pubmed: 33292168
Dis Markers. 2016;2016:7648215
pubmed: 27667893
Nat Commun. 2016 Apr 20;7:11309
pubmed: 27095304
Trends Biochem Sci. 2013 Dec;38(12):612-20
pubmed: 24239264
Am J Cancer Res. 2015 Apr 15;5(5):1602-9
pubmed: 26175931
Biomed Pharmacother. 2016 Feb;77:37-44
pubmed: 26796263
Mol Cancer Ther. 2015 Feb;14(2):429-39
pubmed: 25504751
Lancet. 2019 Jul 6;394(10192):64-80
pubmed: 31178151
J Cancer. 2020 Apr 6;11(13):3976-3985
pubmed: 32328201
Nat Rev Cancer. 2005 Sep;5(9):726-34
pubmed: 16148885
Head Neck. 2022 Jul;44(7):1576-1587
pubmed: 35394102
Cancer Lett. 2014 Feb 1;343(1):24-32
pubmed: 24041865
Biochem Biophys Res Commun. 2013 Nov 29;441(4):958-63
pubmed: 24220341
J Oncol. 2021 Dec 17;2021:6060762
pubmed: 34956364
Dev Cell. 2006 Dec;11(6):859-71
pubmed: 17141160
Carcinogenesis. 2013 Feb;34(2):454-63
pubmed: 23125220
Mol Cancer. 2014 Mar 08;13:51
pubmed: 24606633
Nature. 2004 Mar 18;428(6980):332-7
pubmed: 15029198
IUBMB Life. 2021 Apr;73(4):618-642
pubmed: 33476088
Nat Struct Mol Biol. 2012 Jun 05;19(6):586-93
pubmed: 22664986
Oncogene. 2012 Oct 11;31(41):4421-33
pubmed: 22249270
Biosci Rep. 2019 Nov 29;39(11):
pubmed: 31658358
Exp Ther Med. 2022 Feb;23(2):136
pubmed: 35069817
J Clin Lab Anal. 2022 Feb;36(2):e24194
pubmed: 35028969
Arch Physiol Biochem. 2020 Aug 14;:1-6
pubmed: 32795216
Oncotarget. 2016 Mar 22;7(12):13634-50
pubmed: 26872369
Nat Rev Drug Discov. 2005 Dec;4(12):988-1004
pubmed: 16341064
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Cells. 2020 Mar 18;9(3):
pubmed: 32197467
Braz J Med Biol Res. 2020 Oct 30;53(12):e9740
pubmed: 33146288
J Transl Med. 2022 Jun 8;20(1):264
pubmed: 35676661
Oncotarget. 2016 Jan 19;7(3):3047-58
pubmed: 26655091
Adv Drug Deliv Rev. 2015 Jun 29;87:3-14
pubmed: 25979468
Front Pharmacol. 2018 Dec 11;9:1362
pubmed: 30618730
Oncotarget. 2015 Sep 29;6(29):28341-56
pubmed: 26314966
Genes (Basel). 2021 Nov 21;12(11):
pubmed: 34828441
Front Oncol. 2021 Oct 15;11:720835
pubmed: 34722264
PLoS One. 2013 Oct 23;8(10):e78355
pubmed: 24194922
Nat Rev Cancer. 2006 Apr;6(4):259-69
pubmed: 16557279
Front Pharmacol. 2019 Mar 18;10:253
pubmed: 30936832
Nat Rev Mol Cell Biol. 2010 May;11(5):329-41
pubmed: 20379207
Biochem Pharmacol. 2021 Jul;189:114384
pubmed: 33347867
Oncol Rep. 2018 Apr;39(4):1631-1639
pubmed: 29484437
Biomed Pharmacother. 2021 Jan;133:110986
pubmed: 33166764
J Cell Physiol. 2019 Aug;234(10):17912-17924
pubmed: 30834525
Iran J Basic Med Sci. 2019 May;22(5):541-546
pubmed: 31217935
Cell Mol Biol (Noisy-le-grand). 2020 Oct 31;66(7):44-50
pubmed: 33287921
Med Sci Monit Basic Res. 2019 Feb 18;25:53-62
pubmed: 30773530
Curr Cancer Drug Targets. 2022;22(5):388-403
pubmed: 34970954
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Feb 28;47(2):165-173
pubmed: 35545406
Apoptosis. 2004 Nov;9(6):667-76
pubmed: 15505410
Cell Res. 2014 Jan;24(1):24-41
pubmed: 24366339
Int J Mol Sci. 2020 Dec 26;22(1):
pubmed: 33375317
Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2688-2700
pubmed: 30251659
Onco Targets Ther. 2019 Aug 26;12:6917-6925
pubmed: 31692593
Cell Commun Signal. 2014 Oct 11;12:66
pubmed: 25304455
FASEB J. 2019 Nov;33(11):11959-11972
pubmed: 31408612
Crit Rev Oncol Hematol. 2016 Jul;103:1-9
pubmed: 27179594
Clin Cancer Res. 2007 Dec 15;13(24):7421-31
pubmed: 18094426
Front Oncol. 2021 Dec 20;11:738252
pubmed: 34988010
Neoplasma. 2019 Sep;66(5):825-829
pubmed: 31129965
Kaohsiung J Med Sci. 2017 Sep;33(9):427-432
pubmed: 28865599
PLoS One. 2013 Dec 19;8(12):e84486
pubmed: 24367666
Mol Cell Biochem. 2021 Jun;476(6):2317-2335
pubmed: 33582947
Radiat Oncol. 2021 Oct 11;16(1):198
pubmed: 34635145
Int J Mol Sci. 2021 Jun 28;22(13):
pubmed: 34203300
Cancer Sci. 2021 Jun;112(6):2393-2404
pubmed: 33728743
Gene. 2019 Aug 20;710:103-113
pubmed: 31158447
Cancers (Basel). 2019 Jul 05;11(7):
pubmed: 31284467
Ther Adv Med Oncol. 2020 Aug 27;12:1758835920937890
pubmed: 32922520
Int J Mol Sci. 2021 Sep 11;22(18):
pubmed: 34575999
Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1765-77
pubmed: 17035381
PLoS One. 2015 Apr 23;10(4):e0119015
pubmed: 25906254
Cancers (Basel). 2021 Aug 29;13(17):
pubmed: 34503179
Anticancer Drugs. 2020 Apr;31(4):385-393
pubmed: 31913198
Semin Cancer Biol. 2012 Apr;22(2):166-72
pubmed: 22178394
J Exp Clin Cancer Res. 2016 Dec 5;35(1):188
pubmed: 27919278
Cell Mol Biol (Noisy-le-grand). 2018 Oct 30;64(13):21-25
pubmed: 30403591
Cancer Cell Int. 2017 Mar 1;17:32
pubmed: 28265202
Front Oncol. 2020 Feb 05;10:104
pubmed: 32117754
Front Cell Dev Biol. 2020 Apr 16;8:232
pubmed: 32373608
Drug Discov Today. 2019 Oct;24(10):2086-2095
pubmed: 31173912
Biomolecules. 2019 Apr 17;9(4):
pubmed: 30999672
Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11096-11104
pubmed: 33215426
Front Oncol. 2021 Feb 25;11:605988
pubmed: 33718157
Diagnostics (Basel). 2020 Aug 19;10(9):
pubmed: 32825179
PLoS One. 2014 Aug 28;9(8):e106098
pubmed: 25165983
Semin Cancer Biol. 2019 Dec;59:125-132
pubmed: 31323288
Cancer Biomark. 2018;23(1):107-123
pubmed: 29991129
Mol Med Rep. 2018 Jun;17(6):8244-8252
pubmed: 29693120
Eur Rev Med Pharmacol Sci. 2018 Apr;22(8):2321-2327
pubmed: 29762835
J Exp Clin Cancer Res. 2019 Apr 8;38(1):151
pubmed: 30961650
PLoS One. 2014 Jan 31;9(1):e87767
pubmed: 24498188
Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):7935-7942
pubmed: 31599418
Nat Commun. 2015 Jul 02;6:7353
pubmed: 26135619
Nature. 2004 Sep 16;431(7006):350-5
pubmed: 15372042
Cancer Treat Rev. 2019 Sep;79:101890
pubmed: 31470314
BMC Cancer. 2019 Jan 24;19(1):104
pubmed: 30678643
Oncol Rep. 2020 Apr;43(4):1169-1186
pubmed: 32323781
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1524-1532
pubmed: 31919282
Am J Cancer Res. 2021 Dec 15;11(12):5833-5855
pubmed: 35018228
J Cell Physiol. 2019 May;234(5):5451-5465
pubmed: 30471116
J Nanobiotechnology. 2022 Jun 14;20(1):279
pubmed: 35701788
Semin Cancer Biol. 2019 Dec;59:147-160
pubmed: 31128298
Eur Rev Med Pharmacol Sci. 2019 Jun;23(11):4940-4947
pubmed: 31210329
J Cell Physiol. 2020 May;235(5):4146-4152
pubmed: 31663122
BMC Cancer. 2016 Mar 15;16:218
pubmed: 26975503
Biosci Rep. 2019 Sep 13;39(9):
pubmed: 31471531
Cell. 2009 May 29;137(5):873-86
pubmed: 19446321
Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):12867-12877
pubmed: 33378037
Lancet Oncol. 2015 Jun;16(6):645-55
pubmed: 25957714
Nat Commun. 2018 Nov 27;9(1):5009
pubmed: 30479336
Biomed Pharmacother. 2018 Sep;105:633-644
pubmed: 29898430
Biomark Res. 2022 May 3;10(1):28
pubmed: 35505392
Clin Exp Med. 2022 Jan 15;:
pubmed: 35031885
Acta Pharmacol Sin. 2012 Aug;33(8):981-2
pubmed: 22751478
Biochem Biophys Res Commun. 2014 Feb 7;444(2):199-204
pubmed: 24440701
Cell Death Dis. 2019 Feb 21;10(3):176
pubmed: 30792382
Genes Genomics. 2020 Aug;42(8):971-978
pubmed: 32648233
Front Oncol. 2022 Mar 24;12:819128
pubmed: 35402264
Mol Cell. 2015 Feb 19;57(4):708-720
pubmed: 25639470
J Clin Oncol. 2015 Oct 10;33(29):3346-55
pubmed: 26351340
Cell Death Dis. 2019 Apr 3;10(4):305
pubmed: 30944308
Life Sci. 2021 Nov 15;285:119984
pubmed: 34592229
Int J Biol Sci. 2022 Feb 21;18(5):1878-1895
pubmed: 35342334
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033819892251
pubmed: 31984860
J Biol Chem. 2013 Mar 1;288(9):6034-44
pubmed: 23300087
J Ovarian Res. 2019 Dec 9;12(1):121
pubmed: 31815639
Expert Rev Proteomics. 2019 Jun;16(6):475-485
pubmed: 31056975
J Cell Biochem. 2019 Jun;120(6):10186-10194
pubmed: 30582216
Cancer Biol Ther. 2017 Sep 2;18(9):681-693
pubmed: 28799829
Nat Rev Cancer. 2006 Nov;6(11):857-66
pubmed: 17060945
Signal Transduct Target Ther. 2020 Oct 23;5(1):245
pubmed: 33093441
Life Sci. 2020 Dec 1;262:118480
pubmed: 32980391
Int J Mol Med. 2013 Apr;31(4):904-12
pubmed: 23426850
Cell Cycle. 2012 Feb 15;11(4):785-96
pubmed: 22374676
Oncol Res. 2018 Apr 10;26(3):363-372
pubmed: 28560951
Int J Biochem Cell Biol. 2021 Dec;141:106092
pubmed: 34626803
Front Immunol. 2021 Sep 09;12:680955
pubmed: 34566954
Am J Cancer Res. 2021 Jun 15;11(6):2508-2520
pubmed: 34249413