Association between Nutritional Status and Treatment Response and Survival in Patients Treated with Immunotherapy for Lung Cancer: A Retrospective French Study.
advanced cancer
immunotherapy
lung cancer
nutritional status
survival
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 Jul 2022
15 Jul 2022
Historique:
received:
30
05
2022
revised:
07
07
2022
accepted:
13
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Malnutrition is associated with a greater risk of morbidity and mortality and lower tolerance to chemotherapy. Our purpose was to study the association between nutritional status and the efficiency and tolerance of immunotherapy in non-small cell lung cancer (NSCLC). Nutritional and oncological data were reported at 2 months (M2) and 4 months (M4) after the initiation of immunotherapy (M0). The influence of nutritional status at M0 was estimated with the efficacy and toxicity of immunotherapy at M2 to M4. In total, 127 patients were included in the study, and nutritional status was estimated at M0 for 120 patients: 67% were not malnourished, 20% presented with moderate malnutrition, and 13% presented with severe malnutrition. There was no significant link between the nutritional status at M0 and the toxicity of immunotherapy at M2 and M4. However, severe malnutrition was significantly associated with treatment efficacy at M2 (
Identifiants
pubmed: 35884500
pii: cancers14143439
doi: 10.3390/cancers14143439
pmc: PMC9322139
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Clin Oncol. 2017 Dec 10;35(35):3924-3933
pubmed: 29023213
Proc Nutr Soc. 2018 Nov;77(4):394-402
pubmed: 29708079
Support Care Cancer. 2007 Jan;15(1):39-46
pubmed: 16786329
J Thorac Oncol. 2009 May;4(5):595-601
pubmed: 19276834
Clin Nutr. 2020 Oct;39(10):3005-3013
pubmed: 32037284
Future Oncol. 2010 Apr;6(4):503-13
pubmed: 20373865
J Clin Oncol. 2015 Jan 1;33(1):90-9
pubmed: 25422490
Eur J Clin Pharmacol. 2022 Jan;78(1):77-87
pubmed: 34410448
Clin Cancer Res. 2018 Dec 1;24(23):5787-5789
pubmed: 30018117
J Clin Med. 2019 Apr 03;8(4):
pubmed: 30987236
Ann Transl Med. 2021 Nov;9(21):1630
pubmed: 34926674
Support Care Cancer. 2020 Apr;28(4):1877-1889
pubmed: 31359182
Sports Med Health Sci. 2020 Dec;2(4):177-185
pubmed: 34447946
N Engl J Med. 2015 Jul 9;373(2):123-35
pubmed: 26028407
Support Care Cancer. 2004 Apr;12(4):246-52
pubmed: 14997369
Nat Rev Cancer. 2013 May;13(5):328-41
pubmed: 23612460
Int J Biol Markers. 2018 Nov;33(4):372-378
pubmed: 30282502
Eur J Cancer. 2019 Mar;109:12-20
pubmed: 30654225
Cell Metab. 2016 Nov 8;24(5):672-684
pubmed: 27829137
Transl Lung Cancer Res. 2021 Aug;10(8):3538-3549
pubmed: 34584855
Lancet Oncol. 2011 May;12(5):489-95
pubmed: 21296615
Br J Cancer. 2003 Sep 15;89(6):1028-30
pubmed: 12966420
Lancet Oncol. 2016 Dec;17(12):e542-e551
pubmed: 27924752
J Cachexia Sarcopenia Muscle. 2021 Jun;12(3):657-664
pubmed: 33951326
Radiother Oncol. 2018 Jan;126(1):81-88
pubmed: 29111172
Lung Cancer. 2020 May;143:19-26
pubmed: 32200137
Cancer Manag Res. 2020 Jul 09;12:5597-5605
pubmed: 32753972
J Immunother Cancer. 2019 Feb 27;7(1):57
pubmed: 30813970
Support Care Cancer. 2003 Oct;11(10):652-9
pubmed: 12920623
Ann Oncol. 2018 May 1;29(5):1141-1153
pubmed: 29788170
Support Care Cancer. 2022 Apr;30(4):3119-3129
pubmed: 34862578
Ann Transl Med. 2016 Jul;4(14):268
pubmed: 27563655
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Lung Cancer Manag. 2020 Apr 24;9(2):LMT31
pubmed: 32346405
Ann Oncol. 2021 Aug;32(8):1025-1033
pubmed: 34022376
J Clin Oncol. 2005 Mar 1;23(7):1431-8
pubmed: 15684319
N Engl J Med. 2015 Oct 22;373(17):1627-39
pubmed: 26412456
Ther Adv Med Oncol. 2019 Nov 13;11:1758835919880084
pubmed: 31762796
Am J Med. 1980 Oct;69(4):491-7
pubmed: 7424938
Nat Rev Cancer. 2014 Nov;14(11):754-62
pubmed: 25291291
Anticancer Res. 2020 Dec;40(12):7067-7075
pubmed: 33288604
Nat Rev Dis Primers. 2018 Jan 18;4:17105
pubmed: 29345251
Bull Cancer. 2016 Nov;103(11):949-950
pubmed: 27816168
Ann Oncol. 2019 May;30(5):863-870
pubmed: 31987360
J Palliat Med. 2001 Summer;4(2):157-65
pubmed: 11441624
JAMA Netw Open. 2019 Nov 1;2(11):e1915138
pubmed: 31747030
Int J Mol Sci. 2020 Jan 15;21(2):
pubmed: 31952311
Cancer Treat Rev. 2013 Aug;39(5):534-40
pubmed: 22995477
Clin Nutr. 2018 Aug;37(4):1101-1113
pubmed: 28734552
Br J Cancer. 2017 Sep 26;117(7):913-920
pubmed: 28950287
Nat Rev Drug Discov. 2015 Jan;14(1):58-74
pubmed: 25549588
Lung Cancer (Auckl). 2016 Jan 27;7:1-9
pubmed: 28210155
Br J Cancer. 2010 Mar 16;102(6):966-71
pubmed: 20160725