3D Disease Modelling of Hard and Soft Cancer Using PHA-Based Scaffolds.

breast cancer colon cancer epithelial-mesenchymal transition (EMT) polyhydroxyalkanoates (PHAs) scaffold tumour modelling

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
21 Jul 2022
Historique:
received: 28 06 2022
accepted: 18 07 2022
entrez: 27 7 2022
pubmed: 28 7 2022
medline: 28 7 2022
Statut: epublish

Résumé

Tumour cells are shown to change shape and lose polarity when they are cultured in 3D, a feature typically associated with tumour progression in vivo, thus making it significant to study cancer cells in an environment that mimics the in vivo milieu. In this study we established hard (MCF7 and MDA-MB-231, breast cancer) and soft (HCT116, colon cancer) 3D cancer tumour models utilizing a blend of P(3HO-

Identifiants

pubmed: 35884609
pii: cancers14143549
doi: 10.3390/cancers14143549
pmc: PMC9321847
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : UK-India Education and Research Initiative
ID : UGC-UKIERI 2016-17-013

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Auteurs

Akanksha Tomar (A)

School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.

Pinar Uysal-Onganer (P)

Cancer Research Group, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London W1W 6UW, UK.

Pooja Basnett (P)

School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London W1W 6XH, UK.

Uttam Pati (U)

School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.

Ipsita Roy (I)

Department of Materials Science and Engineering, Faculty of Engineering, University of Sheffield, Sheffield S10 2TN, UK.

Classifications MeSH