NF-κB: A Druggable Target in Acute Myeloid Leukemia.
NF-κB
NF-κB inhibitors
acute myeloid leukemia
cancer therapy
targeted therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
21 Jul 2022
21 Jul 2022
Historique:
received:
06
07
2022
revised:
18
07
2022
accepted:
19
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy that relies on highly heterogeneous cytogenetic alterations. Although in the last few years new agents have been developed for AML treatment, the overall survival prospects for AML patients are still gloomy and new therapeutic options are still urgently needed. Constitutive NF-κB activation has been reported in around 40% of AML patients, where it sustains AML cell survival and chemoresistance. Given the central role of NF-κB in AML, targeting the NF-κB pathway represents an attractive strategy to treat AML. This review focuses on current knowledge of NF-κB's roles in AML pathogenesis and summarizes the main therapeutic approaches used to treat NF-κB-driven AML.
Identifiants
pubmed: 35884618
pii: cancers14143557
doi: 10.3390/cancers14143557
pmc: PMC9319319
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Progetto di Ricerca di Ateneo per la Ricerca di Base - University of L'Aquila
ID : 07_Progetto_Ricerca_Ateneo_Verzella
Organisme : intramural DISCAB GRANT 2021 awarded
ID : DISCAB GRANT 2021_Verzella
Organisme : National operational Programme (PON) - Attraction and International Mobility (AIM) Research and Innovation 2014 - 2020
ID : AIM1855453
Organisme : Ministry of Education, Universities and Research
ID : 2017WLKYAM_1 to FZ
Références
Cells. 2016 Mar 29;5(2):
pubmed: 27043634
Semin Hematol. 2012 Jul;49(3):258-62
pubmed: 22726549
Oncogene. 2014 May 1;33(18):2395-404
pubmed: 23686307
Leukemia. 2020 Mar;34(3):682-696
pubmed: 31919472
Cancer Discov. 2014 Mar;4(3):362-75
pubmed: 24346116
Biomedicines. 2017 Aug 22;5(3):
pubmed: 28829404
Crit Rev Oncog. 2011;16(1-2):93-102
pubmed: 22150310
Blood. 2011 Feb 24;117(8):2348-57
pubmed: 21148331
J Immunol. 2002 Jan 15;168(2):744-54
pubmed: 11777968
Nat Rev Clin Oncol. 2017 Jul;14(7):417-433
pubmed: 28117417
N Engl J Med. 1999 Sep 30;341(14):1051-62
pubmed: 10502596
Cell Death Differ. 2006 May;13(5):785-97
pubmed: 16528384
Apoptosis. 2008 Sep;13(9):1148-61
pubmed: 18670883
Future Sci OA. 2019 Jan 29;5(3):FSO372
pubmed: 30906568
Cancer. 2013 Aug 1;119(15):2728-36
pubmed: 23633004
Nat Commun. 2021 Jan 11;12(1):241
pubmed: 33431824
Blood. 2005 Jan 15;105(2):804-11
pubmed: 15454494
Blood. 2005 Nov 1;106(9):3150-9
pubmed: 16014563
Blood. 2007 Dec 15;110(13):4427-35
pubmed: 17804695
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9184-9
pubmed: 21576471
Crit Rev Oncol Hematol. 2016 Feb;98:35-44
pubmed: 26490297
Ther Adv Hematol. 2014 Jun;5(3):65-77
pubmed: 24883179
Leuk Res. 2005 Aug;29(8):893-9
pubmed: 15978940
Ann Hematol. 2016 Aug;95(8):1211-21
pubmed: 27297971
Biochem J. 2013 May 1;451(3):427-37
pubmed: 23441730
Blood. 2012 Oct 25;120(17):3397-406
pubmed: 22898602
J Biol Chem. 2003 Jan 17;278(3):1450-6
pubmed: 12403772
Front Pharmacol. 2021 May 03;12:672536
pubmed: 34012401
Pharm Res. 2019 Jun 24;36(9):125
pubmed: 31236772
Blood. 2014 Feb 6;123(6):905-13
pubmed: 24363397
Int J Cancer. 2013 Dec 1;133(11):2706-19
pubmed: 23686525
Nat Rev Mol Cell Biol. 2003 Nov;4(11):842-54
pubmed: 14625535
Nat Med. 2013 Feb;19(2):202-8
pubmed: 23291630
J Clin Invest. 2014 Feb;124(2):528-42
pubmed: 24382349
Blood. 2014 Nov 13;124(20):3130-40
pubmed: 25287709
Cancer Discov. 2022 Jul 6;12(7):1617-1619
pubmed: 35791696
Blood. 2009 Feb 26;113(9):2003-13
pubmed: 18952893
Blood. 2014 Apr 10;123(15):2401-11
pubmed: 24464015
Leukemia. 2010 Apr;24(4):699-705
pubmed: 20111068
Acta Haematol. 2001;106(3):95-9
pubmed: 11713373
Nat Med. 2018 Dec;24(12):1859-1866
pubmed: 30420752
Leuk Res. 2021 Jun;105:106573
pubmed: 33915463
Blood. 2011 Dec 15;118(25):6626-37
pubmed: 22021368
Cancer Cell. 2012 Apr 17;21(4):577-92
pubmed: 22516264
Cell Death Differ. 2018 Mar;25(4):642-644
pubmed: 29511335
Blood. 2010 Dec 16;116(25):5638-49
pubmed: 20889924
Cell. 2007 May 4;129(3):617-31
pubmed: 17482553
Cells. 2018 Oct 20;7(10):
pubmed: 30347849
Nanomedicine (Lond). 2017 Feb;12(3):195-205
pubmed: 28102776
Blood. 2008 Mar 1;111(5):2854-65
pubmed: 18160664
Genes Immun. 2019 Nov;20(8):641-650
pubmed: 31110240
Bioorg Med Chem. 2017 Jul 15;25(14):3694-3705
pubmed: 28545815
Blood. 2008 Feb 15;111(4):2364-73
pubmed: 18083845
Semin Cell Dev Biol. 2020 Feb;98:118-128
pubmed: 31132468
J Cell Mol Med. 2021 Mar;25(6):3124-3135
pubmed: 33599085
Pharm Biol. 2016 Aug;54(8):1303-11
pubmed: 26134921
Biochem Pharmacol. 2006 Nov 15;72(10):1311-21
pubmed: 16984800
Foods. 2017 Oct 22;6(10):
pubmed: 29065496
Cancer Discov. 2022 Jul 6;12(7):1760-1781
pubmed: 35405016
Cell Rep. 2014 Sep 11;8(5):1328-38
pubmed: 25199827
Blood. 2008 May 1;111(9):4797-808
pubmed: 18270328
J Exp Med. 2014 Jun 2;211(6):1093-108
pubmed: 24842373
Am J Cancer Res. 2011;1(2):192-221
pubmed: 21969033
Lancet. 2018 Aug 18;392(10147):593-606
pubmed: 30078459
J Med Chem. 2016 Feb 25;59(4):1330-9
pubmed: 26815195
Oncogene. 1999 Nov 22;18(49):6853-66
pubmed: 10602461
Drug Discov Today. 2013 Sep;18(17-18):894-905
pubmed: 23688583
Am J Cancer Res. 2020 Dec 01;10(12):4085-4097
pubmed: 33414987
Leukemia. 2007 May;21(5):877-85
pubmed: 17330097
Nat Immunol. 2011 Jul 19;12(8):689-94
pubmed: 21772277
Cell Death Differ. 2010 Apr;17(4):689-98
pubmed: 19911008
Mediators Inflamm. 2012;2012:416036
pubmed: 22745523
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16220-5
pubmed: 12451177
Br J Haematol. 2011 Apr;153(2):222-35
pubmed: 21375523
Cancers (Basel). 2019 Oct 02;11(10):
pubmed: 31581671
Blood Adv. 2018 Dec 26;2(24):3608-3617
pubmed: 30567725
J Clin Oncol. 1999 Mar;17(3):1071-9
pubmed: 10071302
Blood Adv. 2018 Jun 26;2(12):1409-1411
pubmed: 29914972
Leukemia. 2002 Jan;16(1):150-1
pubmed: 11840275
J Cancer Res Ther. 2016 Jan-Mar;12(1):155-60
pubmed: 27072230
Clin Cancer Res. 2000 May;6(5):1796-803
pubmed: 10815900
Leukemia. 2009 Feb;23(2):365-74
pubmed: 18987666
Biomedicines. 2018 Mar 26;6(2):
pubmed: 29587428
Blood. 2017 Jun 29;129(26):3403-3406
pubmed: 28546144
Drug Resist Updat. 2020 Jan;48:100663
pubmed: 31785545
J Exp Med. 2014 Jan 13;211(1):1-4
pubmed: 24395889
Cell Mol Life Sci. 2014 Jun;71(11):2083-102
pubmed: 24419302
Br J Haematol. 2013 Oct;163(1):139-42
pubmed: 23826785
Neoplasma. 2013;60(6):666-75
pubmed: 23906301
Br J Haematol. 2013 Apr;161(1):57-67
pubmed: 23356405
Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10431-4
pubmed: 1720541
Cancer Cell. 2007 Nov;12(5):457-66
pubmed: 17996649
Cancer Biol Med. 2017 Aug;14(3):254-270
pubmed: 28884042
Oncotarget. 2017 Jun 6;8(23):36936-36949
pubmed: 28415808
Molecules. 2019 Jun 03;24(11):
pubmed: 31163672
J Cancer. 2021 Mar 5;12(9):2570-2581
pubmed: 33854618
Cells. 2020 Jul 12;9(7):
pubmed: 32664684
Int J Mol Sci. 2020 Apr 27;21(9):
pubmed: 32349210
Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210
pubmed: 23486281
Clin Cancer Res. 2009 Jun 1;15(11):3820-6
pubmed: 19458051
Am J Hematol. 2019 Nov;94(11):E291-E294
pubmed: 31379016
iScience. 2021 Nov 12;24(12):103425
pubmed: 34877491
Leukemia. 2012 Jul;26(7):1462-70
pubmed: 22354205
Nature. 2011 Aug 03;478(7370):524-8
pubmed: 21814200
Blood Adv. 2020 Apr 14;4(7):1478-1491
pubmed: 32282883
Oncol Rep. 2017 Sep;38(3):1517-1524
pubmed: 28713903
Nat Rev Drug Discov. 2009 Jan;8(1):33-40
pubmed: 19116625
Biomedicines. 2018 Feb 06;6(1):
pubmed: 29415456
Oncotarget. 2018 Mar 30;9(24):16917-16931
pubmed: 29682194
Exp Hematol. 2013 Jun;41(6):530-538.e1
pubmed: 23416210
Front Oncol. 2019 Jan 29;9:16
pubmed: 30761268
Cancer Res. 2004 Dec 15;64(24):8939-44
pubmed: 15604256
J Hematol Oncol. 2018 Dec 4;11(1):133
pubmed: 30514344
Cancer Chemother Pharmacol. 2011 Jul;68(1):97-105
pubmed: 20844879
Cancer Cell. 2010 Apr 13;17(4):333-47
pubmed: 20385359
Front Immunol. 2021 Oct 15;12:775128
pubmed: 34721441
Blood. 1999 Oct 15;94(8):2844-53
pubmed: 10515888
Clin Cancer Res. 2007 Mar 1;13(5):1516-22
pubmed: 17332297
J Exp Med. 2011 Jun 6;208(6):1189-201
pubmed: 21555486
Blood. 2005 Jun 1;105(11):4163-9
pubmed: 15687234
Oncotarget. 2018 Sep 7;9(70):33416-33439
pubmed: 30279971
Cancer Res. 2017 Jan 15;77(2):494-508
pubmed: 28069801
Blood. 2016 Jan 7;127(1):53-61
pubmed: 26660429
Leukemia. 2004 Jan;18(1):103-12
pubmed: 14574326
Neoplasia. 2012 Dec;14(12):1097-101
pubmed: 23308042
Case Rep Hematol. 2019 Apr 11;2019:6707506
pubmed: 31110828
Leukemia. 2009 Jul;23(7):1252-6
pubmed: 19322210
Blood. 2003 Aug 1;102(3):987-95
pubmed: 12689943
Mol Cancer Ther. 2019 Mar;18(3):567-578
pubmed: 30679386
Br J Cancer. 2015 Jan 20;112(2):232-7
pubmed: 25290089
Oncogene. 2015 Jan 29;34(5):537-45
pubmed: 24632603
Blood Cancer J. 2016 Dec 2;6(12):e503
pubmed: 27911437
Oncotarget. 2011 Sep;2(9):658-68
pubmed: 21911919
Blood. 2019 Jan 3;133(1):7-17
pubmed: 30361262
N Engl J Med. 2015 Sep 17;373(12):1136-52
pubmed: 26376137
Exp Hematol. 2013 Dec;41(12):1005-7
pubmed: 24084080
Nature. 2010 Dec 23;468(7327):1119-23
pubmed: 21068722
Cancer Res. 2007 Feb 15;67(4):1689-95
pubmed: 17308110
Oncotarget. 2017 Jan 31;8(5):8420-8435
pubmed: 28039479
Genes Dev. 2004 Sep 15;18(18):2195-224
pubmed: 15371334
Leukemia. 2018 Nov;32(11):2374-2387
pubmed: 29743719
Gastroenterology. 2010 Jun;138(6):2101-2114.e5
pubmed: 20420949
Cancer Lett. 2002 Jun 6;180(1):91-101
pubmed: 11911975
World J Stem Cells. 2018 Apr 26;10(4):34-42
pubmed: 29707103
Leukemia. 2002 Oct;16(10):2062-71
pubmed: 12357358
Blood. 2002 May 1;99(9):3367-75
pubmed: 11964305
Mol Cell Proteomics. 2013 Mar;12(3):626-37
pubmed: 23233446
Nitric Oxide. 2008 Sep;19(2):170-6
pubmed: 18460349
Blood. 2014 Apr 24;123(17):2691-702
pubmed: 24599548
J Biochem Mol Toxicol. 2012 Jan;26(1):35-43
pubmed: 21928377
Ther Adv Hematol. 2017 Sep;8(9):245-261
pubmed: 29051803
Blood. 2012 Jul 26;120(4):858-67
pubmed: 22685174
Cancer Lett. 2013 Jun 10;333(2):133-46
pubmed: 23376257
Immunity. 2019 Jul 16;51(1):27-41
pubmed: 31315034
Signal Transduct Target Ther. 2020 Sep 21;5(1):209
pubmed: 32958760
J Hematop. 2009 Mar;2(1):2-8
pubmed: 19669217
Haematologica. 2012 Feb;97(2):219-26
pubmed: 21993666
Front Oncol. 2013 May 16;3:120
pubmed: 23720710
Eur J Med Chem. 2018 Sep 5;157:562-581
pubmed: 30121494
Leukemia. 2008 May;22(5):915-31
pubmed: 18288131
Sci Transl Med. 2015 Mar 18;7(279):279ra40
pubmed: 25787766
Mol Cell Biol. 2009 Mar;29(5):1375-87
pubmed: 19103749
Blood. 2000 Sep 1;96(5):1655-69
pubmed: 10961860
Clin Cancer Res. 2012 Jan 15;18(2):360-369
pubmed: 22096027
J Biol Chem. 2013 Nov 22;288(47):33542-33558
pubmed: 24089526
Cell Stem Cell. 2014 Mar 6;14(3):275-91
pubmed: 24607403
Expert Rev Anticancer Ther. 2013 Mar;13(3):327-37
pubmed: 23477519
Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034
pubmed: 20066092
Blood. 2008 Apr 1;111(7):3793-801
pubmed: 18202225
Int J Mol Sci. 2020 Jul 21;21(14):
pubmed: 32708302
Cancer Med. 2020 Apr;9(8):2603-2610
pubmed: 32059085
Mol Cancer Res. 2005 Oct;3(10):585-96
pubmed: 16254192
Oncogene. 2009 Feb 26;28(8):1099-109
pubmed: 19079347
Blood. 2014 Feb 20;123(8):1229-38
pubmed: 24307721
Haematologica. 2020 Jul;105(7):1879-1886
pubmed: 32029509
Cell. 2010 Mar 19;140(6):883-99
pubmed: 20303878
Ann N Y Acad Sci. 2004 Dec;1028:289-93
pubmed: 15650254
Nat Immunol. 2010 Sep;11(9):799-805
pubmed: 20711193
Cancer Invest. 2000;18(8):768-80
pubmed: 11107447
Oncotarget. 2017 Jan 31;8(5):7946-7963
pubmed: 27974700
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Nat Rev Drug Discov. 2014 May;13(5):337-56
pubmed: 24751816
Mol Cell. 2014 Oct 23;56(2):219-231
pubmed: 25263595
J Clin Oncol. 2010 Jun 1;28(16):2739-47
pubmed: 20439648
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6
pubmed: 16885212
Lipids Health Dis. 2018 Apr 2;17(1):62
pubmed: 29606130
Cell Death Dis. 2019 Feb 21;10(3):177
pubmed: 30792387
Cell Rep. 2018 Jan 9;22(2):350-358
pubmed: 29320732
Blood. 2001 Oct 15;98(8):2301-7
pubmed: 11588023
N Engl J Med. 2017 Aug 3;377(5):454-464
pubmed: 28644114
Nat Commun. 2019 Oct 25;10(1):4869
pubmed: 31653912
Int J Biochem Cell Biol. 2018 Feb;95:108-112
pubmed: 29277662
J Biol Chem. 1998 Jan 16;273(3):1288-97
pubmed: 9430659