Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
11 Jul 2022
Historique:
received: 16 06 2022
revised: 07 07 2022
accepted: 08 07 2022
entrez: 27 7 2022
pubmed: 28 7 2022
medline: 29 7 2022
Statut: epublish

Résumé

A colorectal adenoma, an aberrantly growing tissue, arises from the intestinal epithelium and is considered as precursor of colorectal cancer (CRC). In this study, we investigated structural and numerical chromosomal aberrations in adenomas, hypothesizing that chromosomal instability (CIN) occurs early in adenomas. We applied array comparative genomic hybridization (aCGH) to fresh frozen colorectal adenomas and their adjacent mucosa from 16 patients who underwent colonoscopy examination. In our study, histologically similar colorectal adenomas showed wide variability in chromosomal instability. Based on the obtained results, we further stratified patients into four distinct groups. The first group showed the gain of

Identifiants

pubmed: 35887000
pii: ijms23147656
doi: 10.3390/ijms23147656
pmc: PMC9318831
pii:
doi:

Substances chimiques

MALAT1 long non-coding RNA, human 0
RNA, Long Noncoding 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Grant Agency of the Ministry of Health of the Czech Republic
ID : AZV NV18-03-00199
Organisme : Grant Agency of the Czech Republic
ID : GACR 22-05942S
Organisme : Cooperatio Program
ID : Oncology and Haematology
Organisme : Grant Schemes project at UK
ID : CZ.02.2.69/0.0/0.0/19_073 project n. START/MED/052

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Auteurs

Anna Siskova (A)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Albertov 4, 128 00 Prague, Czech Republic.

Jan Kral (J)

Clinic of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.

Jana Drabova (J)

Department of Biology and Medical Genetics, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, 150 06 Prague, Czech Republic.

Klara Cervena (K)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Albertov 4, 128 00 Prague, Czech Republic.

Kristyna Tomasova (K)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.

Jiri Jungwirth (J)

Institute of Physiology, 1st Faculty of Medicine Charles University, Katerinska 1660/32, 121 08 Praha, Czech Republic.
Department of Gastroenterology, Libera Scientia, Lucni 7a, 130 00 Prague, Czech Republic.
Department of General, Visceral and Thoracic Surgery, Klinikum Weiden, Söllnerstraße 16, 92637 Weiden, Germany.

Tomas Hucl (T)

Clinic of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.

Pavel Kohout (P)

Department of Internal Medicine, 3rd Faculty of Medicine University and Faculty Thomayer Hospital Prague, Ruska 87, 100 00 Prague, Czech Republic.

Sandra Summerova (S)

Department of Internal Medicine, 3rd Faculty of Medicine University and Faculty Thomayer Hospital Prague, Ruska 87, 100 00 Prague, Czech Republic.

Ludmila Vodickova (L)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Albertov 4, 128 00 Prague, Czech Republic.
Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.

Pavel Vodicka (P)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Albertov 4, 128 00 Prague, Czech Republic.
Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.

Veronika Vymetalkova (V)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Albertov 4, 128 00 Prague, Czech Republic.
Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.

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