Impact of Metabolic Surgery on Gut Microbiota and Sera Metabolomic Patterns among Patients with Diabetes.
metabolic surgery
metabolomics
microbiota
obesity
type 2 diabetes mellitus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Jul 2022
14 Jul 2022
Historique:
received:
01
06
2022
revised:
10
07
2022
accepted:
12
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Metabolic surgery is a promising treatment for obese individuals with type 2 diabetes mellitus (T2DM), but the mechanism is not completely understood. Current understanding of the underlying ameliorative mechanisms relies on alterations in parameters related to the gastrointestinal hormones, biochemistry, energy absorption, the relative composition of the gut microbiota, and sera metabolites. A total of 13 patients with obesity and T2DM undergoing metabolic surgery treatments were recruited. Systematic changes of critical parameters and the effects and markers after metabolic surgery, in a longitudinal manner (before surgery and three, twelve, and twenty-four months after surgery) were measured. The metabolomics pattern, gut microbiota composition, together with the hormonal and biochemical characterizations, were analyzed. Body weight, body mass index, total cholesterol, triglyceride, fasting glucose level, C-peptide, HbA1c, HOMA-IR, gamma-glutamyltransferase, and des-acyl ghrelin were significantly reduced two years after metabolic surgery. These were closely associated with the changes of sera metabolomics and gut microbiota. Significant negative associations were found between the
Identifiants
pubmed: 35887145
pii: ijms23147797
doi: 10.3390/ijms23147797
pmc: PMC9320451
pii:
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Taipei Veterans General Hospital
ID : V107C-088, V108C-062, and V109C-120
Organisme : Chang Gung Memorial Hospital
ID : CORPD1J0052
Organisme : Taiwan Ministry of Science and Technology
ID : MOST 103-2314-B-010-011-, MOST 109-2320-B-182-034-MY3, MOST109-2327-B-182-001
Organisme : Taiwan Ministry of Education and Taiwan Ministry of Science and Technology
ID : MOST 109-2634-F-182-001
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