Are We Ready to Implement Molecular Subtyping of Bladder Cancer in Clinical Practice? Part 2: Subtypes and Divergent Differentiation.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
16 Jul 2022
Historique:
received: 23 06 2022
revised: 09 07 2022
accepted: 12 07 2022
entrez: 27 7 2022
pubmed: 28 7 2022
medline: 29 7 2022
Statut: epublish

Résumé

Following several attempts to achieve a molecular stratification of bladder cancer (BC) over the last decade, a "consensus" classification has been recently developed to provide a common base for the molecular classification of bladder cancer (BC), encompassing a six-cluster scheme with distinct prognostic and predictive characteristics. In order to implement molecular subtyping (MS) as a risk stratification tool in routine practice, immunohistochemistry (IHC) has been explored as a readily accessible, relatively inexpensive, standardized surrogate method, achieving promising results in different clinical settings. The second part of this review deals with the pathological and clinical features of the molecular clusters, both in conventional and divergent urothelial carcinoma, with a focus on the role of IHC-based subtyping.

Identifiants

pubmed: 35887192
pii: ijms23147844
doi: 10.3390/ijms23147844
pmc: PMC9317362
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Francesca Sanguedolce (F)

Pathology Unit, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.

Magda Zanelli (M)

Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.

Andrea Palicelli (A)

Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.

Stefano Ascani (S)

Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy.

Maurizio Zizzo (M)

Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.

Giorgia Cocco (G)

Radiotherapy Unit, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.

Lars Björnebo (L)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Solna, Sweden.

Anna Lantz (A)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Solna, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Solna, Sweden.

Matteo Landriscina (M)

Department of Medical and Surgical Sciences, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.

Vincenza Conteduca (V)

Department of Medical and Surgical Sciences, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.

Ugo Giovanni Falagario (UG)

Department of Urology and Renal Transplantation, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.

Luigi Cormio (L)

Department of Urology and Renal Transplantation, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.
Department of Urology, Bonomo Teaching Hospital, 76123 Andria, Italy.

Giuseppe Carrieri (G)

Department of Urology and Renal Transplantation, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.

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