Roles of Keratins in Intestine.
CRC
IBD
intestine
keratin
transgenic mice
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jul 2022
21 Jul 2022
Historique:
received:
06
06
2022
revised:
19
07
2022
accepted:
19
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Keratins make up a major portion of epithelial intermediate filament proteins. The widely diverse keratins are found in both the small and large intestines. The human intestine mainly expresses keratins 8, 18, 19, and 20. Many of the common roles of keratins are for the integrity and stability of the epithelial cells. The keratins also protect the cells and tissue from stress and are biomarkers for some diseases in the organs. Although an increasing number of studies have been performed regarding keratins, the roles of keratin in the intestine have not yet been fully understood. This review focuses on discussing the roles of keratins in the intestine. Diverse studies utilizing mouse models and samples from patients with intestinal diseases in the search for the association of keratin in intestinal diseases have been summarized.
Identifiants
pubmed: 35887395
pii: ijms23148051
doi: 10.3390/ijms23148051
pmc: PMC9317181
pii:
doi:
Substances chimiques
Intermediate Filament Proteins
0
Keratins
68238-35-7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Korean Ministry of Education, Science, and Technology
ID : grant 2018R1D1A1A02086060
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