Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma.
VEGF-C
VEGFR-3
biliary neoplasia
cancer-associated fibroblasts
lymphatic vessel
tumor microenvironment
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
30 Jun 2022
30 Jun 2022
Historique:
received:
09
05
2022
revised:
23
06
2022
accepted:
29
06
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
The prognosis of cholangiocarcinoma remains poor in spite of the advances in immunotherapy and molecular profiling, which has led to the identification of several targetable genetic alterations. Surgical procedures, including both liver resection and liver transplantation, still represent the treatment with the best curative potential, though the outcomes are significantly compromised by the early development of lymph node metastases. Progression of lymphatic metastasis from the primary tumor to tumor-draining lymph nodes is mediated by tumor-associated lymphangiogenesis, a topic largely overlooked until recently. Recent findings highlight tumor-associated lymphangiogenesis as paradigmatic of the role played by the tumor microenvironment in sustaining cholangiocarcinoma invasiveness and progression. This study reviews the current knowledge about the intercellular signaling and molecular mechanism of tumor-associated lymphangiogenesis in cholangiocarcinoma in the hope of identifying novel therapeutic targets to halt a process that often limits the success of the few available treatments.
Identifiants
pubmed: 35887583
pii: jpm12071086
doi: 10.3390/jpm12071086
pmc: PMC9324584
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Italian Association for Cancer Research
ID : 24858
Organisme : NIH HHS
ID : P30 DK034989
Pays : United States
Organisme : European Cooperation in Science and Technology
ID : CA18122
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034989
Pays : United States
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