Effect of Pravastatin and Simvastatin on the Reduction of Cytochrome C.
apoptosis
cytochrome c
hypercholesterolemia
mitochondrial oxygen consumption
preeclampsia
statins
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
10 Jul 2022
10 Jul 2022
Historique:
received:
19
05
2022
revised:
04
07
2022
accepted:
07
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Statins are used to treat hypercholesterolemia, with several pleiotropic effects. Alongside their positive effects (for example, decreasing blood pressure), they can also bring about negative effects/symptoms (such as myopathy). Their main mechanism of action is inducing apoptosis, the key step being the release of cytochrome c from the mitochondria. This can be facilitated by oxidative stress, through which glutathione is oxidized. In this research, glutathione was used as a respiratory substrate to measure the mitochondrial oxygen consumption of rat liver with an O
Identifiants
pubmed: 35887618
pii: jpm12071121
doi: 10.3390/jpm12071121
pmc: PMC9321872
pii:
doi:
Types de publication
Journal Article
Langues
eng
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