Pineal Gland from the Cell Culture to Animal Models: A Review.
animal models
cell culture
melatonin
neurodegenerative process
regeneration
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
15 Jul 2022
15 Jul 2022
Historique:
received:
03
06
2022
revised:
05
07
2022
accepted:
12
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
This review demonstrates current literature on pineal gland physiology, pathology, and animal model experiments to concisely explore future needs in research development with respect to pineal gland function and neuro-regenerative properties. The pineal gland plays an integral role in sleep and recovery by promoting physiologic circadian rhythms via production and release of melatonin. Yet, the current literature shows that the pineal gland has neuroprotective effects that modulate both peripheral and central nerve injuries through several direct and indirect mechanisms, such as angiogenesis and induction of growth factors and anti-inflammatory mediators. Animal models have also shown correlations between pineal gland function and metabolic homeostasis. Studies have shown that a functional pineal gland is essential in preventing and slowing the progression of certain diseases such as diabetes, osteoporosis, vertebral osteoarthritis, and neurodegenerative processes. Lastly, the array of cell culturing methods and animal models that can be used to further develop the study of pineal gland function and nervous system injury were reviewed.
Identifiants
pubmed: 35888145
pii: life12071057
doi: 10.3390/life12071057
pmc: PMC9317964
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Edward Via College of Osteopathic Medicine
ID : intramural Edward Via College of Osteopathic Medicine
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