Therapeutic Strategies to Reduce Burn Wound Conversion.
biologics
burns
inflammation
wounds and injuries
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
11 Jul 2022
11 Jul 2022
Historique:
received:
10
06
2022
revised:
02
07
2022
accepted:
08
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper wounds in need of excision. While no current treatment can definitively stop burn wound conversion, attempts to slow tissue damage remain unsatisfactory, justifying the need for new therapeutic interventions. To attenuate burn wound conversion, various studies have targeted at least one of the molecular mechanisms underlying burn wound conversion, including ischemia, inflammation, apoptosis, autophagy, generation of reactive oxygen species, hypothermia, and wound rehydration. However, therapeutic strategies that can target various mechanisms involved in burn wound conversion are still lacking. This review highlights the pathophysiology of burn wound conversion and focuses on recent studies that have turned to the novel use of biologics such as mesenchymal stem cells, biomaterials, and immune regulators to mitigate wound conversion. Future research should investigate mechanistic pathways, side effects, safety, and efficacy of these different treatments before translation into clinical studies.
Identifiants
pubmed: 35888643
pii: medicina58070922
doi: 10.3390/medicina58070922
pmc: PMC9315582
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Arch Surg. 2001 Sep;136(9):1084
pubmed: 11529835
Expert Opin Pharmacother. 2019 Feb;20(3):305-321
pubmed: 30517046
Trials. 2019 Feb 13;20(1):130
pubmed: 30760332
Burns Trauma. 2020 Oct 02;8:tkaa024
pubmed: 33033727
Cell Tissue Bank. 2002;3(1):29-35
pubmed: 15256897
Commun Integr Biol. 2010 May;3(3):278-81
pubmed: 20714413
J Burn Care Res. 2021 Nov 24;42(6):1232-1242
pubmed: 34145458
Immunopharmacology. 1999 May;42(1-3):195-202
pubmed: 10408380
Burns. 2004 Dec;30(8):843-50
pubmed: 15555800
Am J Surg. 2020 Nov;220(5):1323-1326
pubmed: 32660698
J Biomed Mater Res A. 2014 May;102(5):1527-36
pubmed: 23765644
Int J Mol Sci. 2019 Mar 05;20(5):
pubmed: 30841550
Ann Plast Surg. 2018 Dec;81(6):715-724
pubmed: 30260837
J Trauma. 1969 Oct;9(10):839-62
pubmed: 4898658
Medicina (Kaunas). 2021 Feb 23;57(2):
pubmed: 33672128
Ulus Travma Acil Cerrahi Derg. 2020 Jun;26(4):517-525
pubmed: 32589233
Burns. 2020 Dec;46(8):1924-1932
pubmed: 32660829
Int Wound J. 2017 Feb;14(1):89-96
pubmed: 26688157
Oncotarget. 2017 Mar 28;8(13):20706-20718
pubmed: 28157701
Wound Repair Regen. 2013 Jan-Feb;21(1):35-43
pubmed: 23110665
J Invest Surg. 2019 Sep;32(6):477-490
pubmed: 29442525
Burns. 2009 Sep;35(6):757-67
pubmed: 19482429
N Engl J Med. 1986 Apr 10;314(15):948-53
pubmed: 2938005
Br J Surg. 1953 May;40(164):588-96
pubmed: 13059343
J Plast Reconstr Aesthet Surg. 2013 Feb;66(2):260-6
pubmed: 23059135
Plast Reconstr Surg Glob Open. 2021 Feb 17;9(2):e3383
pubmed: 33680645
Shock. 2007 May;27(5):507-19
pubmed: 17438456
Wound Repair Regen. 2012 Jul-Aug;20(4):563-72
pubmed: 22712482
Ann Plast Surg. 2007 Jul;59(1):109-15
pubmed: 17589272
Burns. 2013 Mar;39(2):320-5
pubmed: 22853970
Cochrane Database Syst Rev. 2014 Dec 15;(12):CD006215
pubmed: 25500895
Foods. 2017 Oct 22;6(10):
pubmed: 29065496
Wound Repair Regen. 2013 Nov-Dec;21(6):852-9
pubmed: 23980869
J Surg Res. 2010 Jan;158(1):112-20
pubmed: 19394637
Biochem J. 1984 Aug 15;222(1):1-15
pubmed: 6383353
Adv Skin Wound Care. 2019 Mar;32(3):1-4
pubmed: 30801355
Acad Emerg Med. 2013 Apr;20(4):398-402
pubmed: 23701348
Burns. 2016 Aug;42(5):1025-1035
pubmed: 26787127
Burns. 2001 Nov;27(7):739-46
pubmed: 11600254
Trends Cell Biol. 2011 Jul;21(7):387-92
pubmed: 21561772
Am J Transl Res. 2019 Feb 15;11(2):655-668
pubmed: 30899369
J Burn Care Res. 2006 Jan-Feb;27(1):18-25
pubmed: 16566533
Adv Exp Med Biol. 2007;595:105-25
pubmed: 17569207
Sci Rep. 2021 Jun 14;11(1):12457
pubmed: 34127701
J Investig Med. 2021 Mar;69(3):761-767
pubmed: 33361403
Nat Rev Mol Cell Biol. 2014 Feb;15(2):81-94
pubmed: 24401948
Wound Repair Regen. 2013 Jul-Aug;21(4):563-70
pubmed: 23627744
Pediatr Nephrol. 1994 Jun;8(3):357-66
pubmed: 7917869
Semin Immunol. 2009 Jun;21(3):110-20
pubmed: 19369094
Front Pharmacol. 2021 Jun 14;12:679580
pubmed: 34194330
Burns. 2019 May;45(3):746-748
pubmed: 30826150
J Invest Dermatol. 2010 Feb;130(2):362-70
pubmed: 19675575
Ann Surg. 1974 Jul;180(1):98-102
pubmed: 4835963
J Burn Care Rehabil. 2001 Nov-Dec;22(6):406-16
pubmed: 11761393
Inflammation. 2015 Feb;38(1):312-26
pubmed: 25270658
Burns. 2018 Dec;44(8):2059-2063
pubmed: 30274809
Redox Biol. 2021 Sep;45:102034
pubmed: 34139550
J Plast Reconstr Aesthet Surg. 2018 Aug;71(8):1196-1206
pubmed: 29748072
Burns. 2000 Feb;26(1):41-5
pubmed: 10630318
J Immunol. 2010 May 15;184(10):5423-8
pubmed: 20483798
Phytother Res. 2019 Feb;33(2):422-430
pubmed: 30461085
Bioengineered. 2015;6(3):153-60
pubmed: 25837446
Ulus Travma Acil Cerrahi Derg. 2020 Dec;27(1):9-16
pubmed: 33394467
Mol Cell Endocrinol. 2018 Feb 5;461:256-264
pubmed: 28935544
J Burn Care Res. 2011 Nov-Dec;32(6):647-53
pubmed: 21979853
Plast Reconstr Surg. 1997 May;99(6):1610-9
pubmed: 9145131
J Burn Care Res. 2012 Jul-Aug;33(4):544-51
pubmed: 22447201
Burns Trauma. 2021 Sep 11;9:tkab021
pubmed: 34514007
J Burn Care Res. 2020 Feb 19;41(2):427-432
pubmed: 31602477
Br J Surg. 2012 Sep;99(9):1295-303
pubmed: 22829457
Plast Reconstr Surg. 1980 Aug;66(2):191-8
pubmed: 7403309
J Wound Care. 2021 Sep 02;30(Sup9a):VIIIi-VIIIx
pubmed: 34570634
Burns. 2013 Dec;39(8):1551-6
pubmed: 23751274
Plast Reconstr Surg. 2016 Mar;137(3):566e-575e
pubmed: 26910701
Acad Emerg Med. 2008 Jun;15(6):549-54
pubmed: 18616442
Wound Repair Regen. 2016 Jan-Feb;24(1):6-13
pubmed: 26609910
Acad Emerg Med. 2014 Apr;21(4):383-91
pubmed: 24730400
Burns. 2012 Feb;38(1):95-101
pubmed: 22079539
Evid Based Complement Alternat Med. 2020 Feb 13;2020:6462956
pubmed: 32148546
Am Fam Physician. 2009 Aug 1;80(3):265-9
pubmed: 19621836
J Burn Care Res. 2011 Jan-Feb;32(1):135-42
pubmed: 21088615
Int J Antimicrob Agents. 2018 Mar;51(3):299-303
pubmed: 28887201
Results Probl Cell Differ. 2017;62:353-364
pubmed: 28455716
Burns. 2016 May;42(3):571-7
pubmed: 26655279
PLoS One. 2017 Jun 14;12(6):e0179350
pubmed: 28614412
Macromol Biosci. 2020 Jun;20(6):e2000036
pubmed: 32239626
J Drugs Dermatol. 2015 Jul;14(7):726-32
pubmed: 26151790
Crit Care Med. 2013 Apr;41(4):963-71
pubmed: 23324953
Burns. 2015 Dec;41(8):1775-1787
pubmed: 26392023
World J Surg. 2004 Mar;28(3):307-11
pubmed: 14961187
Wound Repair Regen. 2008 May-Jun;16(3):321-30
pubmed: 18471250
Plast Reconstr Surg. 2013 Mar;131(3):463-471
pubmed: 23446561
Front Pharmacol. 2018 Oct 31;9:951
pubmed: 30429786
Life Sci. 2021 Jul 1;276:119095
pubmed: 33493522
Trends Cell Biol. 2012 Feb;22(2):107-15
pubmed: 22209517
Burns. 2020 Sep;46(6):1389-1397
pubmed: 32362363
Burns. 2001 Jun;27(4):349-58
pubmed: 11348743
Ann Plast Surg. 2011 Jun;66(6):607-9
pubmed: 21508812
Burns. 2021 Jun;47(4):970-972
pubmed: 33531185
Toxicology. 2003 Jul 15;189(1-2):75-88
pubmed: 12821284
Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):503-10
pubmed: 19201690
Burns. 2013 May;39(3):436-44
pubmed: 23149435
Front Bioeng Biotechnol. 2020 Sep 15;8:553037
pubmed: 33072719
Burns. 2010 Jun;36(4):539-44
pubmed: 19766400
J Oncol. 2013;2013:102735
pubmed: 23840208