Characterization and Comparison of Ocular Surface Microbiome in Newborns.
16S rRNA sequencing
bacteria
newborn
ocular surface microbiota
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
10 Jul 2022
10 Jul 2022
Historique:
received:
02
06
2022
revised:
29
06
2022
accepted:
06
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
The ocular microbiome is of fundamental importance for immune eye homeostasis, and its alteration would lead to an impairment of ocular functionality. Little evidence is reported on the composition of the ocular microbiota of term infants and on the impact of antibiotic prophylaxis. A total of 20 conjunctival swabs were collected from newborns at birth and after antibiotic treatment. Samples were subjected to 16S rRNA sequencing via system MiSeq Illumina. The data were processed with the MicrobAT software and statistical analysis were performed using two-way ANOVA. Antibiotic prophylaxis with gentamicin altered the composition of the microbiota. In detail, a 1.5- and 2.01-fold reduction was recorded for Antibiotic prophylaxis altered the ocular microbiota whose understanding could avoid adverse effects on eye health.
Identifiants
pubmed: 35889110
pii: microorganisms10071390
doi: 10.3390/microorganisms10071390
pmc: PMC9320102
pii:
doi:
Types de publication
Journal Article
Langues
eng
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