New Organoselenium (NSAIDs-Selenourea and Isoselenocyanate) Derivatives as Potential Antiproliferative Agents: Synthesis, Biological Evaluation and in Silico Calculations.
Adenocarcinoma
Anti-Inflammatory Agents, Non-Steroidal
/ pharmacology
Antineoplastic Agents
/ chemistry
Apoptosis
Cell Line, Tumor
Cell Proliferation
Colonic Neoplasms
Drug Screening Assays, Antitumor
Humans
Molecular Docking Simulation
Molecular Structure
Organoselenium Compounds
Structure-Activity Relationship
Urea
/ analogs & derivatives
NSAIDs
antiproliferative
isoselenocyanate
selenourea
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Jul 2022
06 Jul 2022
Historique:
received:
17
05
2022
revised:
27
06
2022
accepted:
27
06
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
In this study, we report on the synthesis of new organoselenium derivatives, including nonsteroidal anti-inflammatory drugs (NSAIDs) scaffolds and Se functionalities (isoselenocyanate and selenourea), which were evaluated against four types of cancer cell line: SW480 (human colon adenocarcinoma cells), HeLa (human cervical cancer cells), A549 (human lung carcinoma cells), MCF-7 (human breast adenocarcinoma cells). Among these compounds, most of the investigated compounds reduced the viability of different cancer cell lines. The most promising compound
Identifiants
pubmed: 35889201
pii: molecules27144328
doi: 10.3390/molecules27144328
pmc: PMC9320890
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Antineoplastic Agents
0
Organoselenium Compounds
0
isoselenocyanate
0
selenourea
0W506YR523
Urea
8W8T17847W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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