In Situ Transformation of Electrospun Nanofibers into Nanofiber-Reinforced Hydrogels.
biomaterial
coaxial electrospinning
composite material
mechanical properties
tissue engineering
wound healing
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
16 Jul 2022
16 Jul 2022
Historique:
received:
04
07
2022
revised:
12
07
2022
accepted:
14
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Nanofiber-reinforced hydrogels have recently gained attention in biomedical engineering. Such three-dimensional scaffolds show the mechanical strength and toughness of fibers while benefiting from the cooling and absorbing properties of hydrogels as well as a large pore size, potentially aiding cell migration. While many of such systems are prepared by complicated processes where fibers are produced separately to later be embedded in a hydrogel, we here provide proof of concept for a one-step solution. In more detail, we produced core-shell nanofibers from the natural proteins zein and gelatin by coaxial electrospinning. Upon hydration, the nanofibers were capable of directly transforming into a nanofiber-reinforced hydrogel, where the nanofibrous structure was retained by the zein core, while the gelatin-based shell turned into a hydrogel matrix. Our nanofiber-hydrogel composite showed swelling to ~800% of its original volume and water uptake of up to ~2500% in weight. The physical integrity of the nanofiber-reinforced hydrogel was found to be significantly improved in comparison to a hydrogel system without nanofibers. Additionally, tetracycline hydrochloride was incorporated into the fibers as an antimicrobial agent, and antimicrobial activity against
Identifiants
pubmed: 35889661
pii: nano12142437
doi: 10.3390/nano12142437
pmc: PMC9318765
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : LEO Foundation
ID : LF17063
Références
Chempluschem. 2019 Oct;84(10):1453-1497
pubmed: 31943926
Int J Biol Macromol. 2020 Dec 1;164:976-985
pubmed: 32710964
Int J Pharm. 2022 Jun 10;621:121809
pubmed: 35550408
J Mater Chem B. 2020 Jul 22;8(28):6115-6127
pubmed: 32558871
Biofabrication. 2019 Dec 19;12(1):015020
pubmed: 31675730
ACS Nano. 2018 Nov 27;12(11):10772-10784
pubmed: 30481960
Expert Opin Drug Deliv. 2018 Jan;15(1):65-75
pubmed: 28662354
Acta Biomater. 2016 Jun;37:155-64
pubmed: 27079762
J Vis Exp. 2019 Jan 7;(143):
pubmed: 30663697
Microorganisms. 2021 Oct 19;9(10):
pubmed: 34683497
Biomaterials. 2011 Oct;32(28):6729-36
pubmed: 21683438
J Mater Chem B. 2020 Nov 4;8(42):9794-9803
pubmed: 33030182
Mol Biotechnol. 2018 Jul;60(7):506-532
pubmed: 29761314
Tissue Eng Part B Rev. 2010 Aug;16(4):371-83
pubmed: 20121414
Carbohydr Polym. 2021 Jan 1;251:117023
pubmed: 33142583
Int J Pharm. 2011 Aug 30;415(1-2):34-52
pubmed: 21640806
Biomaterials. 2017 Sep;138:153-168
pubmed: 28578293
Pharmaceutics. 2020 Dec 22;13(1):
pubmed: 33374930
ACS Appl Bio Mater. 2019 Mar 18;2(3):952-969
pubmed: 35021385
Int J Mol Sci. 2020 Aug 12;21(16):
pubmed: 32806616
Exp Dermatol. 2021 Sep;30(9):1218-1232
pubmed: 34009648
ACS Appl Mater Interfaces. 2012 Aug;4(8):4331-7
pubmed: 22839659
Tissue Eng Part B Rev. 2011 Oct;17(5):365-72
pubmed: 21815802
Adv Mater. 2014 Dec 17;26(47):8029-33
pubmed: 25381870
J Biomater Appl. 2022 May;36(10):1852-1862
pubmed: 35225041
Nanomedicine. 2013 Apr;9(3):322-35
pubmed: 23178282
Nanotechnology. 2012 Mar 9;23(9):095705
pubmed: 22322583
Materials (Basel). 2019 Aug 04;12(15):
pubmed: 31382665
J Biomater Sci Polym Ed. 2014;25(18):2009-22
pubmed: 25357002
Materials (Basel). 2021 Jan 14;14(2):
pubmed: 33466924
Polymers (Basel). 2020 Sep 03;12(9):
pubmed: 32899245
ACS Appl Mater Interfaces. 2020 Apr 8;12(14):15989-16005
pubmed: 32172559
J Tissue Eng Regen Med. 2018 Jun;12(6):1313-1326
pubmed: 29489058
Front Microbiol. 2021 Jan 12;11:607099
pubmed: 33510726
Int J Biol Macromol. 2019 Sep 15;137:392-404
pubmed: 31233795
Pharmaceutics. 2020 May 18;12(5):
pubmed: 32443445
ACS Appl Mater Interfaces. 2016 Sep 21;8(37):24415-25
pubmed: 27559926
J Colloid Interface Sci. 2020 Apr 1;565:416-425
pubmed: 31982708
Int J Biol Macromol. 2022 Mar 31;202:438-452
pubmed: 35063481
J Funct Biomater. 2020 Sep 22;11(3):
pubmed: 32971968
Int J Pharm. 2013 Nov 1;456(1):165-74
pubmed: 23948135
Molecules. 2019 Mar 05;24(5):
pubmed: 30841558
ACS Biomater Sci Eng. 2020 Oct 12;6(10):5453-5473
pubmed: 33320571
J Control Release. 2021 Jun 10;334:463-484
pubmed: 33781809
Gels. 2022 Feb 17;8(2):
pubmed: 35200508
Tissue Eng Part B Rev. 2020 Jun;26(3):230-248
pubmed: 31928151
Pharmaceutics. 2020 Dec 07;12(12):
pubmed: 33297493
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Macromol Rapid Commun. 2015 May;36(10):909-15
pubmed: 25790157
Membranes (Basel). 2021 Oct 09;11(10):
pubmed: 34677536
J Biomater Appl. 2020 Oct-Nov;35(4-5):515-531
pubmed: 32600090