Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia.
dietary supplement
hypercholesterolemia
inflammatory profile
lipid profile
monacolin K-free
nutraceutical combination
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
08 Jul 2022
08 Jul 2022
Historique:
received:
09
06
2022
revised:
30
06
2022
accepted:
06
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Nutraceutical combinations (NCs) against hypercholesterolemia are increasing in the marketplace. However, the availability of NCs without monacolin K is scarce even though the statin-intolerant population needs it. This study is a parallel-group, randomized, placebo-controlled, double-blind trial. We evaluated the effects of the NC containing phytosterols, bergamot, olive fruits, and vitamin K Compared to the placebo, at 6 and 12 weeks, NC did not significantly reduce total cholesterol ( The evaluated nutraceutical combination did not change serum lipid profile and inflammatory parameters, at least not with the daily dose applied in the present study.
Sections du résumé
BACKGROUND
BACKGROUND
Nutraceutical combinations (NCs) against hypercholesterolemia are increasing in the marketplace. However, the availability of NCs without monacolin K is scarce even though the statin-intolerant population needs it.
METHODS
METHODS
This study is a parallel-group, randomized, placebo-controlled, double-blind trial. We evaluated the effects of the NC containing phytosterols, bergamot, olive fruits, and vitamin K
RESULTS
RESULTS
Compared to the placebo, at 6 and 12 weeks, NC did not significantly reduce total cholesterol (
CONCLUSIONS
CONCLUSIONS
The evaluated nutraceutical combination did not change serum lipid profile and inflammatory parameters, at least not with the daily dose applied in the present study.
Identifiants
pubmed: 35889769
pii: nu14142812
doi: 10.3390/nu14142812
pmc: PMC9324786
pii:
doi:
Substances chimiques
Biomarkers
0
Cholesterol, LDL
0
Lipids
0
MicroRNAs
0
Triglycerides
0
C-Reactive Protein
9007-41-4
Lovastatin
9LHU78OQFD
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Regione Marche, Italy
ID : project PrInT AGE 10439
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