Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway.
Plasmodium falciparum
antibiotics
antimalarial drugs
domiphen bromide
malaria
methyl erythritol phosphate pathway
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
22 Jun 2022
22 Jun 2022
Historique:
received:
16
05
2022
revised:
16
06
2022
accepted:
18
06
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting antimalarials. The apicoplast organelle is a preferred target of antimalarial drugs because it contains biochemical processes absent from the human host. Fosmidomycin is the only drug in clinical trials targeting the apicoplast, where it inhibits the methyl erythritol phosphate (MEP) pathway. Here, we characterized the antiplasmodial activity of domiphen bromide (DB), another MEP pathway inhibitor with a rapid mode of action that arrests the in vitro growth of
Identifiants
pubmed: 35890216
pii: pharmaceutics14071320
doi: 10.3390/pharmaceutics14071320
pmc: PMC9319574
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Science, Innovation and Universities, Spain
ID : RTI2018-094579-B-I00
Organisme : Government of Catalonia
ID : 2017-SGR-908
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