3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related
3D printing
Staphylococcus aureus
bone-related infection
fused filament fabrication
mouse model
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
28 Jun 2022
28 Jun 2022
Historique:
received:
31
05
2022
revised:
19
06
2022
accepted:
20
06
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Bacterial infections are a serious healthcare complication in orthopedic and trauma surgery worldwide. Compared to systemic, local antibiotic prophylaxis has been shown to provide a higher antibiotic dose and bioavailability at the bone site with minimum toxic effects. However, there are still not enough biomaterial and antibiotic combinations available for personalized implant sizes for patients. The aim of this study was to develop a bone fixation plate coating made of a composite of poly-ε-caprolactone, hydroxyapatite and halloysite nanotubes loaded with gentamicin sulphate and fabricated via fused filament fabrication 3D printing technology. The mechanical and thermal properties of the biomaterial were analyzed. The in vitro release kinetics of gentamicin sulphate were evaluated for 14 days showing a burst release during the first two days that was followed by a sustained release of bactericidal concentrations. The composite loaded with 2 and 5% gentamicin sulphate exhibited complete antimicrobial killing of
Identifiants
pubmed: 35890261
pii: pharmaceutics14071363
doi: 10.3390/pharmaceutics14071363
pmc: PMC9320525
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : EU Framework Programme for Research and Innovation Horizon 2020-Marie Skłodowska-Curie Innovative Training Networks
ID : 722467
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