Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders.
drug discovery
drug repurposing
medications
mental disorders
network analysis
psychiatric disorders
psychiatry
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
14 Jul 2022
14 Jul 2022
Historique:
received:
01
06
2022
revised:
30
06
2022
accepted:
12
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Despite advances in pharmacology and neuroscience, the path to new medications for psychiatric disorders largely remains stagnated. Drug repurposing offers a more efficient pathway compared with de novo drug discovery with lower cost and less risk. Various computational approaches have been applied to mine the vast amount of biomedical data generated over recent decades. Among these methods, network-based drug repurposing stands out as a potent tool for the comprehension of multiple domains of knowledge considering the interactions or associations of various factors. Aligned well with the poly-pharmacology paradigm shift in drug discovery, network-based approaches offer great opportunities to discover repurposing candidates for complex psychiatric disorders. In this review, we present the potential of network-based drug repurposing in psychiatry focusing on the incentives for using network-centric repurposing, major network-based repurposing strategies and data resources, applications in psychiatry and challenges of network-based drug repurposing. This review aims to provide readers with an update on network-based drug repurposing in psychiatry. We expect the repurposing approach to become a pivotal tool in the coming years to battle debilitating psychiatric disorders.
Identifiants
pubmed: 35890359
pii: pharmaceutics14071464
doi: 10.3390/pharmaceutics14071464
pmc: PMC9319329
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Health and Medical Research Council
ID : 1078928
Organisme : National Health and Medical Research Council
ID : 1153607
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