A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug-Drug Interaction Modeling.
cytochrome P450 3A4 (CYP3A4)
drug–drug interactions (DDIs)
felodipine
pharmacodynamics
physiologically based pharmacokinetic (PBPK) modeling
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
15 Jul 2022
15 Jul 2022
Historique:
received:
14
06
2022
revised:
12
07
2022
accepted:
13
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
The antihypertensive felodipine is a calcium channel blocker of the dihydropyridine type, and its pharmacodynamic effect directly correlates with its plasma concentration. As a sensitive substrate of cytochrome P450 (CYP) 3A4 with high first-pass metabolism, felodipine shows low oral bioavailability and is susceptible to drug-drug interactions (DDIs) with CYP3A4 perpetrators. This study aimed to develop a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) parent-metabolite model of felodipine and its metabolite dehydrofelodipine for DDI predictions. The model was developed in PK-Sim
Identifiants
pubmed: 35890369
pii: pharmaceutics14071474
doi: 10.3390/pharmaceutics14071474
pmc: PMC9322514
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Federal Ministry of Education and Research
ID : 031L0161C
Références
Clin Pharmacol Ther. 2018 Jun;103(6):1083-1092
pubmed: 28913826
Clin Pharmacol Ther. 2004 Dec;76(6):607-17
pubmed: 15592332
Eur J Clin Pharmacol. 1993;44(2):163-9
pubmed: 8453961
Clin Pharmacol Ther. 1998 Sep;64(3):248-56
pubmed: 9757148
Clin Pharmacokinet. 2016 Dec;55(12):1573-1589
pubmed: 27351180
Pharmacol Res. 2020 Apr;154:104311
pubmed: 31212012
J Cardiovasc Pharmacol. 1988 Aug;12(2):134-9
pubmed: 2459543
Drug Metab Dispos. 2004 Jun;32(6):647-60
pubmed: 15155557
Clin Pharmacol Ther. 1997 Apr;61(4):410-5
pubmed: 9129558
J Clin Pharmacol. 2012 Jan;52(1 Suppl):91S-108S
pubmed: 22232759
Clin Pharmacol Ther. 1985 Aug;38(2):205-11
pubmed: 4017422
Br J Clin Pharmacol. 1989 Jan;27(1):67-74
pubmed: 2706189
CPT Pharmacometrics Syst Pharmacol. 2020 Jun;9(6):322-331
pubmed: 32543786
J Clin Invest. 1997 May 15;99(10):2545-53
pubmed: 9153299
Drug Metab Dispos. 2011 Feb;39(2):170-3
pubmed: 21036951
Eur J Clin Pharmacol. 1989;36(5):473-9
pubmed: 2753065
Drugs. 1987;34 Suppl 3:125-31
pubmed: 3443058
Drugs. 1987;34 Suppl 3:16-27
pubmed: 3327676
Drugs. 1985;29 Suppl 2:144-53
pubmed: 3987541
DICP. 1991 Sep;25(9):1007-8
pubmed: 1949959
Drugs. 1985;29 Suppl 2:109-16
pubmed: 2859183
Pharm Res. 1994 Aug;11(8):1093-7
pubmed: 7971707
J Cardiovasc Pharmacol. 1990 Mar;15(3):428-35
pubmed: 1691367
Drug Metab Dispos. 2011 Sep;39(9):1633-42
pubmed: 21632965
Clin Pharmacol Ther. 2003 Jun;73(6):529-37
pubmed: 12811362
Eur J Pharm Sci. 2012 Sep 29;47(2):375-86
pubmed: 22759901
J Chromatogr. 1990 Jun 29;528(2):343-56
pubmed: 2384574
Clin Pharmacol Ther. 1992 Jul;52(1):80-9
pubmed: 1385566
Ann ICRP. 2002;32(3-4):5-265
pubmed: 14506981
Lancet. 1988 Aug 27;2(8609):480-2
pubmed: 2900404
Clin Pharmacokinet. 1988 Jun;14(6):374-83
pubmed: 3396260
Eur J Clin Pharmacol. 1986;30(2):133-9
pubmed: 3519241
Clin Pharmacol Ther. 1993 Jun;53(6):637-42
pubmed: 8513655
Drug Metab Dispos. 2002 Dec;30(12):1512-22
pubmed: 12433827
Eur J Clin Pharmacol. 1990;38(6):529-33
pubmed: 2373126
Drugs. 1985;29 Suppl 2:176-84
pubmed: 3987546
J Control Release. 2005 Nov 28;108(2-3):375-85
pubmed: 16213057
Eur J Pharm Biopharm. 2020 Oct;155:55-68
pubmed: 32781025
Clin Pharmacol Ther. 2000 Nov;68(5):468-77
pubmed: 11103749
CPT Pharmacometrics Syst Pharmacol. 2018 Oct;7(10):647-659
pubmed: 30091221
Eur J Clin Pharmacol. 2005 Jan;60(11):785-90
pubmed: 15592925
Mycoses. 2018 May;61(5):337-339
pubmed: 29385285
Eur J Clin Pharmacol. 1997;52(2):139-45
pubmed: 9174684
J Am Acad Dermatol. 1995 Jul;33(1):134-5
pubmed: 7601933
Eur J Clin Pharmacol. 1983;24(1):49-53
pubmed: 6832201
Biopharm Drug Dispos. 1987 May-Jun;8(3):235-48
pubmed: 3593901
Br J Clin Pharmacol. 1991 Jan;31(1):15-24
pubmed: 2015166
Clin Pharmacol Ther. 1996 Jul;60(1):25-33
pubmed: 8689808
Br J Clin Pharmacol. 1988 Nov;26(5):557-62
pubmed: 3207560
Eur J Clin Pharmacol. 1995;49(1-2):61-7
pubmed: 8751023
Eur J Clin Pharmacol. 1990;38(5):421-4
pubmed: 2379526
Eur J Clin Pharmacol. 1987;31(5):575-8
pubmed: 3830242
AAPS J. 2011 Dec;13(4):519-47
pubmed: 21818695
Clin Pharmacol Ther. 2000 Jul;68(1):28-34
pubmed: 10945313
Br J Clin Pharmacol. 1990 Jan;29(1):39-45
pubmed: 2404502
Curr Drug Metab. 2007 Aug;8(6):623-30
pubmed: 17691921
Eur Heart J. 2018 Sep 1;39(33):3021-3104
pubmed: 30165516
Genes (Basel). 2020 Dec 16;11(12):
pubmed: 33339226
J Clin Pharmacol. 1990 Nov;30(11):1020-30
pubmed: 2243149
Clin Pharmacol Ther. 1995 May;57(5):569-81
pubmed: 7768080
J Pharm Biomed Anal. 1984;2(3-4):527-36
pubmed: 16867733
Cardiovasc Drugs Ther. 1990 Dec;4(6):1495-500
pubmed: 2081141
Transl Clin Pharmacol. 2019 Mar;27(1):24-32
pubmed: 32055578
Eur J Clin Pharmacol. 1998 Mar;54(1):75-81
pubmed: 9591935
Eur J Clin Pharmacol. 1992;42(3):313-7
pubmed: 1577050
Biomed Chromatogr. 1993 Mar-Apr;7(2):99-103
pubmed: 8485383
J Clin Pharm Ther. 2017 Jun;42(3):345-349
pubmed: 28244604
Drug Metab Dispos. 2016 Nov;44(11):1808-1818
pubmed: 27538919
Nat Rev Dis Primers. 2018 Mar 22;4:18014
pubmed: 29565029
J Cardiovasc Pharmacol. 2010 Dec;56(6):669-75
pubmed: 20881606
Eur J Clin Pharmacol. 1996;50(3):203-8
pubmed: 8737760
Pharmacol Res Perspect. 2017 Oct;5(5):
pubmed: 28971609
J Clin Pharmacol. 2020 Oct;60 Suppl 1:S160-S178
pubmed: 33205429
Basic Clin Pharmacol Toxicol. 2019 Mar;124(3):245-255
pubmed: 30253071
Br J Clin Pharmacol. 1995 Aug;40(2):135-40
pubmed: 8562295
Curr Opin Nephrol Hypertens. 2011 Mar;20(2):113-7
pubmed: 21245763
Pharmaceutics. 2021 Feb 17;13(2):
pubmed: 33671323
Blood Press. 2001;10(4):217-22
pubmed: 11800060
J Pharm Sci. 2018 Jan;107(1):250-256
pubmed: 28826878