Molecular mechanisms underlying bacterial resistance to ceftazidime/avibactam.
ceftazidime/avibactam
efflux pump
outer membrane protein
resistance mechanism
β-lactamase
Journal
WIREs mechanisms of disease
ISSN: 2692-9368
Titre abrégé: WIREs Mech Dis
Pays: United States
ID NLM: 9918227353306676
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
01
05
2022
received:
07
03
2022
accepted:
07
05
2022
pubmed:
28
7
2022
medline:
15
11
2022
entrez:
27
7
2022
Statut:
ppublish
Résumé
Ceftazidime/avibactam (CAZ/AVI), a combination of ceftazidime and a novel β-lactamase inhibitor (avibactam) that has been approved by the U.S. Food and Drug Administration, the European Union, and the National Regulatory Administration in China. CAZ/AVI is used mainly to treat complicated urinary tract infections and complicated intra-abdominal infections in adults, as well as to treat patients infected with Carbapenem-resistant Enterobacteriaceae (CRE) susceptible to CAZ/AVI. However, increased clinical application of CAZ/AVI has resulted in the development of resistant strains. Mechanisms of resistance in most of these strains have been attributed to bla
Identifiants
pubmed: 35891616
doi: 10.1002/wsbm.1571
pmc: PMC9788277
doi:
Substances chimiques
Ceftazidime
9M416Z9QNR
avibactam
7352665165
Anti-Bacterial Agents
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1571Informations de copyright
© 2022 The Authors. WIREs Mechanisms of Disease published by Wiley Periodicals LLC.
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