Spleen transient elastography predicts actuarial survival after liver transplantation.
Spleen
liver transplantation (LTx)
survival
transient elastography (TE)
Journal
Translational gastroenterology and hepatology
ISSN: 2415-1289
Titre abrégé: Transl Gastroenterol Hepatol
Pays: China
ID NLM: 101683450
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
11
2019
accepted:
12
05
2020
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Splenic transient elastography (TE) correlates with increased portal pressure. Little data are available in the post liver transplantation (LTx) setting. Three months after LTx, we performed splenic TE in 125 LTx recipients. Mean splenic TE values were 29.4 (±6.3; range, 21.6-49.2) kPa. Splenic TE correlated with reduced time to development until persistent ascites (30 events, OR =1.082, 95% CI: 1.034-1.133; P=0.001), hepatorenal syndrome (8 events, OR =1.109, 95% CI: 1.015-1.211; P=0.022) and hepatic encephalopathy (16 events, OR =1.136, 95% CI: 1.066-1.211; P=0.000). In Cox univariate analysis, splenic TE served as a predictor of actuarial survival free of liver (OR =1.114, 95% CI: 1.050-1.182; P<0.001) and remained an independent risk factor associated with reduced actuarial survival free of LTx in multivariate analysis (OR =1.103, 95% CI: 1.026-1.186; P=0.008). Splenic TE measurement at 3 months after LTx serves as a robust predictor of survival in LTx recipients.
Sections du résumé
Background
UNASSIGNED
Splenic transient elastography (TE) correlates with increased portal pressure. Little data are available in the post liver transplantation (LTx) setting.
Methods
UNASSIGNED
Three months after LTx, we performed splenic TE in 125 LTx recipients.
Results
UNASSIGNED
Mean splenic TE values were 29.4 (±6.3; range, 21.6-49.2) kPa. Splenic TE correlated with reduced time to development until persistent ascites (30 events, OR =1.082, 95% CI: 1.034-1.133; P=0.001), hepatorenal syndrome (8 events, OR =1.109, 95% CI: 1.015-1.211; P=0.022) and hepatic encephalopathy (16 events, OR =1.136, 95% CI: 1.066-1.211; P=0.000). In Cox univariate analysis, splenic TE served as a predictor of actuarial survival free of liver (OR =1.114, 95% CI: 1.050-1.182; P<0.001) and remained an independent risk factor associated with reduced actuarial survival free of LTx in multivariate analysis (OR =1.103, 95% CI: 1.026-1.186; P=0.008).
Conclusions
UNASSIGNED
Splenic TE measurement at 3 months after LTx serves as a robust predictor of survival in LTx recipients.
Identifiants
pubmed: 35892053
doi: 10.21037/tgh-19-343
pii: tgh-07-19-343
pmc: PMC9257531
doi:
Types de publication
Journal Article
Langues
eng
Pagination
31Commentaires et corrections
Type : CommentIn
Informations de copyright
2022 Translational Gastroenterology and Hepatology. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tgh.amegroups.com/article/view/10.21037/tgh-19-343/coif). The authors have no conflicts of interest to declare.
Références
Liver Int. 2017 Mar;37(3):396-405
pubmed: 27569696
Radiology. 2012 Jun;263(3):893-9
pubmed: 22523326
Gut. 2006 Mar;55(3):403-8
pubmed: 16020491
Hepatology. 2007 Sep;46(3):912-21
pubmed: 17705266
J Hepatol. 2010 Sep;53(3):397-417
pubmed: 20633946
J Hepatol. 2018 Aug;69(2):308-317
pubmed: 29729368
J Am Coll Surg. 2009 May;208(5):896-903; discussion 903-5
pubmed: 19476857
BMC Med Res Methodol. 2012 Jun 19;12:81
pubmed: 22712852
Transplant Proc. 2017 Sep;49(7):1530-1534
pubmed: 28838434
J Hepatol. 2011 Apr;54(4):650-9
pubmed: 21146892
Hepatology. 2005 Jan;41(1):48-54
pubmed: 15690481
Ultrasound Med Biol. 2003 Dec;29(12):1705-13
pubmed: 14698338
Transplant Proc. 2000 May;32(3):539-40
pubmed: 10812103
Aliment Pharmacol Ther. 2006 Sep 1;24(5):797-804
pubmed: 16918883
Hepatology. 2012 Jul;56(1):198-208
pubmed: 22271046
J Gastroenterol Hepatol. 2011 Jan;26(1):164-70
pubmed: 21175810
Gastroenterology. 2013 May;144(5):1152-3
pubmed: 23523840
J Hepatol. 2010 Apr;52(4):529-39
pubmed: 20206401
J Gastrointestin Liver Dis. 2014 Jun;23(2):223-4
pubmed: 24949619
Liver Int. 2015 Feb;35(2):518-23
pubmed: 25074281
Kaohsiung J Med Sci. 2016 Mar;32(3):128-34
pubmed: 27106002
Am J Gastroenterol. 2013 Oct;108(10):1660-1
pubmed: 24091515
Dig Liver Dis. 2002 Feb;34(2):144-50
pubmed: 11926560
Liver Transpl. 2006 Dec;12(12):1791-8
pubmed: 16823833
Hepatology. 2006 Jun;43(6):1317-25
pubmed: 16729309
Liver Int. 2020 Jan;40(1):175-185
pubmed: 31444849
Am J Gastroenterol. 2014 Jan;109(1):134
pubmed: 24402535