IgG
IgG
N-glycans
N-glycome
glycosylation
pemphigus
rituximab
sialic acid
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
22 Jul 2022
22 Jul 2022
Historique:
received:
25
05
2022
revised:
27
06
2022
accepted:
18
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Pemphigus is a life-threatening auto-immune blistering disease of the skin and mucous membrane that is caused by the production of auto-antibodies (auto-Abs) directed against adhesion proteins: desmoglein 1 and 3. We demonstrated in the "Ritux3" trial, the high efficacy of rituximab, an anti-CD20 recombinant monoclonal antibody, as the first-line treatment for pemphigus. However, 25% of patients relapsed during the six-month period after rituximab treatment. These early relapses were associated with a lower decrease in anti-desmoglein auto-Abs after the initial cycle of rituximab. The
Identifiants
pubmed: 35892674
pii: biomedicines10081774
doi: 10.3390/biomedicines10081774
pmc: PMC9330150
pii:
doi:
Types de publication
Journal Article
Langues
eng
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