Clinical Characteristics, Genetic Findings and Arrhythmic Outcomes of Patients with Catecholaminergic Polymorphic Ventricular Tachycardia from China: A Systematic Review.
CPVT
RyR2
catecholaminergic polymorphic ventricular tachycardia
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
22 Jul 2022
22 Jul 2022
Historique:
received:
07
06
2022
revised:
12
07
2022
accepted:
19
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited cardiac ion channelopathy. The present study aims to examine the clinical characteristics, genetic basis, and arrhythmic outcomes of CPVT patients from China to elucidate the difference between CPVT patients in Asia and Western countries. PubMed and Embase were systematically searched for case reports or series reporting on CPVT patients from China until 19 February 2022 using the keyword: "Catecholaminergic Polymorphic Ventricular Tachycardia" or "CPVT", with the location limited to: "China" or "Hong Kong" or "Macau" in Embase, with no language or publication-type restriction. Articles that did not state a definite diagnosis of CPVT and articles with duplicate cases found in larger cohorts were excluded. All the included publications in this review were critically appraised based on the Joanna Briggs Institute Critical Appraisal Checklist. Clinical characteristics, genetic findings, and the primary outcome of spontaneous ventricular tachycardia/ventricular fibrillation (VT/VF) were analyzed. A total of 58 unique cases from 15 studies (median presentation age: 8 (5.0-11.8) years old) were included. All patients, except one, presented at or before 19 years of age. There were 56 patients (96.6%) who were initially symptomatic. Premature ventricular complexes (PVCs) were present in 44 out of 51 patients (86.3%) and VT in 52 out of 58 patients (89.7%). Genetic tests were performed on 54 patients (93.1%) with a yield of 87%. RyR2, CASQ2, TERCL, and SCN10A mutations were found in 35 (71.4%), 12 (24.5%), 1 (0.02%) patient, and 1 patient (0.02%), respectively. There were 54 patients who were treated with beta-blockers, 8 received flecainide, 5 received amiodarone, 2 received verapamil and 2 received propafenone. Sympathectomy ( This was the first systematic review of CPVT patients from China. Most patients had symptoms on initial presentation, with syncope as the presenting complaint. RyR2 mutation accounts for more than half of the CPVT cases, followed by CASQ2, TERCL and SCN10A mutations.
Identifiants
pubmed: 35892906
pii: life12081104
doi: 10.3390/life12081104
pmc: PMC9330865
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Medicine (Baltimore). 2018 Apr;97(16):e0368
pubmed: 29668588
Heart Lung Circ. 2019 Jan;28(1):22-30
pubmed: 30389366
JAMA Cardiol. 2022 May 1;7(5):504-512
pubmed: 35353122
J Med Genet. 2005 Nov;42(11):863-70
pubmed: 16272262
J Mol Cell Cardiol. 2018 Apr;117:26-35
pubmed: 29477366
J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):250-259
pubmed: 23337247
Stem Cell Res. 2019 Aug;39:101509
pubmed: 31382203
Biochem Biophys Res Commun. 2020 Nov 26;533(1):168-174
pubmed: 32948286
Circ J. 2016 Aug 25;80(9):1907-15
pubmed: 27452199
J Arrhythm. 2016 Oct;32(5):344-351
pubmed: 27761157
Zhonghua Xin Xue Guan Bing Za Zhi. 2021 Aug 24;49(8):796-801
pubmed: 34404189
Heart Rhythm. 2013 Dec;10(12):1932-63
pubmed: 24011539
PLoS One. 2016 Apr 21;11(4):e0153851
pubmed: 27100291
Heart. 2013 Apr;99(7):497-504
pubmed: 23390049
Hong Kong Med J. 2016 Aug;22(4):314-9
pubmed: 27256466
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Heart. 2003 Jan;89(1):66-70
pubmed: 12482795
Circulation. 2021 Jul 20;144(3):229-242
pubmed: 33910361
Circ Arrhythm Electrophysiol. 2015 Jun;8(3):633-42
pubmed: 25713214
Am J Cardiol. 2019 Jun 15;123(12):2031-2038
pubmed: 30975432
Heart Rhythm. 2013 Dec;10(12):e85-108
pubmed: 23916535
Chin Med J (Engl). 2018 Dec 5;131(23):2864-2865
pubmed: 30511691
J Am Coll Cardiol. 2020 Jun 2;75(21):2698-2707
pubmed: 32466885
Circ Res. 2006 May 12;98(9):1151-8
pubmed: 16601229
Acta Physiol (Oxf). 2016 Dec;218(4):234-235
pubmed: 27084434
Circ Genom Precis Med. 2018 Jan;11(1):e001817
pubmed: 29874177
Circulation. 2020 Sep 8;142(10):932-947
pubmed: 32693635
Circ J. 2018 Aug 24;82(9):2269-2276
pubmed: 29925740
Int J Cardiol. 2005 Mar 18;99(2):343-5
pubmed: 15749201
Circ Res. 2011 Apr 1;108(7):871-83
pubmed: 21454795
Mol Genet Genomic Med. 2019 Nov;7(11):e949
pubmed: 31482657
J Am Coll Cardiol. 2009 Nov 24;54(22):2065-74
pubmed: 19926015
Int J Cardiol Heart Vasc. 2020 Jan 21;26:100468
pubmed: 31993492
Circulation. 2009 May 12;119(18):2426-34
pubmed: 19398665
Hum Mol Genet. 2021 Dec 27;31(2):157-165
pubmed: 34312669
Ann Noninvasive Electrocardiol. 2016 May;21(3):294-304
pubmed: 26305685
Heart Rhythm. 2021 Nov;18(11):1825-1832
pubmed: 34333088
J Cardiovasc Electrophysiol. 2020 Jun;31(6):1527-1535
pubmed: 32173957
Eur J Hum Genet. 2016 Dec;24(12):1797-1802
pubmed: 27650965
Hong Kong Med J. 2018 Aug;24(4):340-349
pubmed: 29497013
Europace. 2016 Oct;18(10):1587-1592
pubmed: 26705564
Clin Exp Pharmacol Physiol. 2017 Jun;44(6):686-692
pubmed: 28316073
Ann N Y Acad Sci. 2020 Oct;1478(1):63-74
pubmed: 32713021
Europace. 2018 Mar 1;20(3):541-547
pubmed: 28158428
Genet Med. 2015 May;17(5):405-24
pubmed: 25741868
Circulation. 1995 Mar 1;91(5):1512-9
pubmed: 7867192
Pflugers Arch. 2016 Apr;468(4):655-65
pubmed: 26545784
Prog Cardiovasc Dis. 2019 May - Jun;62(3):227-234
pubmed: 31078562
Arch Med Sci. 2019 Nov 12;16(2):466-470
pubmed: 32190159
Circulation. 2019 Jul 30;140(5):390-404
pubmed: 31311300
Eur Heart J. 2021 Mar 31;42(13):1273-1274
pubmed: 33595071
J Electrocardiol. 2018 Mar - Apr;51(2):309-315
pubmed: 29132927
Zhonghua Er Ke Za Zhi. 2019 Sep 2;57(9):700-704
pubmed: 31530356
Europace. 2012 Feb;14(2):175-83
pubmed: 21893508
Circ J. 2013;77(7):1705-13
pubmed: 23595086
J Geriatr Cardiol. 2016 Sep;13(9):811-812
pubmed: 27899947
Zhonghua Xin Xue Guan Bing Za Zhi. 2012 Oct;40(10):844-8
pubmed: 23302672
Circ Cardiovasc Genet. 2017 Feb;10(1):
pubmed: 28087566
Zhonghua Er Ke Za Zhi. 2017 Dec 2;55(12):926-931
pubmed: 29262473
Eur Heart J. 2021 Mar 14;42(11):1082-1090
pubmed: 33221895
J Geriatr Cardiol. 2016 Sep;13(9):813-814
pubmed: 27899948
Chin Med J (Engl). 2006 Dec 20;119(24):2129-33
pubmed: 17199967
Ann Pediatr Cardiol. 2016 May-Aug;9(2):137-46
pubmed: 27212848
Zhonghua Er Ke Za Zhi. 2020 Nov 2;58(11):905-909
pubmed: 33120462
Europace. 2017 Apr 1;19(4):696
pubmed: 28431069
PLoS One. 2018 Nov 7;13(11):e0205925
pubmed: 30403697
Front Cardiovasc Med. 2019 Jul 12;6:92
pubmed: 31380394
J Am Coll Cardiol. 2002 Jul 17;40(2):341-9
pubmed: 12106942
Circ J. 2016 May 25;80(6):1285-91
pubmed: 27180891
J Am Coll Cardiol. 2017 Jul 25;70(4):453-462
pubmed: 28728690
Circulation. 2004 Oct 12;110(15):2119-24
pubmed: 15466642
J Cardiol. 2019 May;73(5):335-342
pubmed: 30910390
Front Cardiovasc Med. 2018 Dec 11;5:176
pubmed: 30619883
Eur Heart J. 2022 Apr 14;43(15):1500-1510
pubmed: 34557911
Cardiol J. 2018;25(6):756-758
pubmed: 30600839
J Am Heart Assoc. 2020 Nov 17;9(22):e012714
pubmed: 33170070
Eur J Med Genet. 2019 Jul;62(7):103631
pubmed: 30790670
Int J Mol Sci. 2021 Jan 12;22(2):
pubmed: 33445410
Eur Heart J Suppl. 2020 Nov 18;22(Suppl L):L105-L109
pubmed: 33654474
Circulation. 2002 Jul 2;106(1):69-74
pubmed: 12093772
Br J Pharmacol. 2018 Apr;175(8):1260-1278
pubmed: 28369767
Heart Rhythm. 2020 Feb;17(2):305-312
pubmed: 31521807
J Clin Invest. 2005 Aug;115(8):2033-8
pubmed: 16075044
Ann Noninvasive Electrocardiol. 2017 Nov;22(6):
pubmed: 27535213
Eur Heart J. 2019 Sep 14;40(35):2964-2975
pubmed: 31170290
Int J Mol Sci. 2020 Mar 01;21(5):
pubmed: 32121523
J Muscle Res Cell Motil. 2020 Sep;41(2-3):251-258
pubmed: 32902830
J Cardiovasc Electrophysiol. 2013 Feb;24(2):210-8
pubmed: 23131176
Biol Res Nurs. 2009 Jul;11(1):66-72
pubmed: 19398417
Cureus. 2021 Feb 18;13(2):e13417
pubmed: 33763313
Circ Res. 2002 Oct 18;91(8):e21-6
pubmed: 12386154