Cardiovascular Risk after Kidney Transplantation: Causes and Current Approaches to a Relevant Burden.
cardiovascular disease
cardiovascular risk factors
kidney transplantation
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
23 Jul 2022
23 Jul 2022
Historique:
received:
29
06
2022
revised:
11
07
2022
accepted:
20
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Cardiovascular disease is a frequent complication after kidney transplantation and represents the leading cause of mortality in this population. We searched for the relevant articles in the National Institutes of Health library of medicine, transplant, cardiologic and nephrological journals. The pathogenesis of cardiovascular disease in kidney transplant is multifactorial. Apart from non-modifiable risk factors, such as age, gender, genetic predisposition and ethnicity, several traditional and non-traditional modifiable risk factors contribute to its development. Traditional factors, such as diabetes, hypertension and dyslipidemia, may be present before and may worsen after transplantation. Immunosuppressants and impaired graft function may strongly influence the exacerbation of these comorbidities. However, in the last years, several studies showed that many other cardiovascular risk factors may be involved in kidney transplantation, including hyperuricemia, inflammation, low klotho and elevated Fibroblast Growth Factor 23 levels, deficient levels of vitamin D, vascular calcifications, anemia and poor physical activity and quality of life. The timely and effective treatment of time-honored and recently discovered modifiable risk factors represent the basis of the prevention of cardiovascular complications in kidney transplantation. Reduction of cardiovascular risk can improve the life expectancy, the quality of life and the allograft function and survival.
Sections du résumé
BACKGROUND
BACKGROUND
Cardiovascular disease is a frequent complication after kidney transplantation and represents the leading cause of mortality in this population.
MATERIAL AND METHODS
METHODS
We searched for the relevant articles in the National Institutes of Health library of medicine, transplant, cardiologic and nephrological journals.
RESULTS
RESULTS
The pathogenesis of cardiovascular disease in kidney transplant is multifactorial. Apart from non-modifiable risk factors, such as age, gender, genetic predisposition and ethnicity, several traditional and non-traditional modifiable risk factors contribute to its development. Traditional factors, such as diabetes, hypertension and dyslipidemia, may be present before and may worsen after transplantation. Immunosuppressants and impaired graft function may strongly influence the exacerbation of these comorbidities. However, in the last years, several studies showed that many other cardiovascular risk factors may be involved in kidney transplantation, including hyperuricemia, inflammation, low klotho and elevated Fibroblast Growth Factor 23 levels, deficient levels of vitamin D, vascular calcifications, anemia and poor physical activity and quality of life.
CONCLUSIONS
CONCLUSIONS
The timely and effective treatment of time-honored and recently discovered modifiable risk factors represent the basis of the prevention of cardiovascular complications in kidney transplantation. Reduction of cardiovascular risk can improve the life expectancy, the quality of life and the allograft function and survival.
Identifiants
pubmed: 35893294
pii: jpm12081200
doi: 10.3390/jpm12081200
pmc: PMC9329988
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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