Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART.
HIV-1
drug resistance
integrase inhibitors
Journal
Infectious disease reports
ISSN: 2036-7430
Titre abrégé: Infect Dis Rep
Pays: Switzerland
ID NLM: 101537203
Informations de publication
Date de publication:
22 Jun 2022
22 Jun 2022
Historique:
received:
05
04
2022
revised:
31
05
2022
accepted:
19
06
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance problems, detected while the patient was on dolutegravir-based cART. We speculate the pre-selection of M184I/V aided the occurrence of G118R in this case, and discuss the robustness of dolutegravir-based therapies.
Identifiants
pubmed: 35893472
pii: idr14040053
doi: 10.3390/idr14040053
pmc: PMC9326666
doi:
Types de publication
Journal Article
Langues
eng
Pagination
501-504Références
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