Optical Imaging Visualizes a Homogeneous and Horizontal Band-Like Biodistribution of Large- and Small-Size Hydrophilic Compounds Delivered by Ablative Fractional Laser.

PD-1 inhibitor ablative fractional CO2 laser antibody biodistribution dermatology ex vivo confocal microscopy laser-assisted drug delivery low pulse energy nivolumab skin

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
23 Jul 2022
Historique:
received: 31 05 2022
revised: 07 07 2022
accepted: 18 07 2022
entrez: 27 7 2022
pubmed: 28 7 2022
medline: 28 7 2022
Statut: epublish

Résumé

The skin barrier generally limits the topical delivery of hydrophilic molecules. Ablative fractional laser (AFL) facilitates cutaneous drug uptake of smaller hydrophilic compounds in several studies. In this imaging-based study, we aim to investigate the cutaneous biodistribution of two different-sized hydrophilic compounds delivered by an ablative fractional CO

Identifiants

pubmed: 35893793
pii: pharmaceutics14081537
doi: 10.3390/pharmaceutics14081537
pmc: PMC9394322
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : LEO Foundation
ID : LF18045
Organisme : Fabrikant Vilhelm Pedersen og Hustrus Legat on the recommendation of The Novo Nordisk Foundation
ID : 0052695

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Auteurs

Rikke Louise Christensen (RL)

Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, 2400 Copenhagen, Denmark.

Vinzent Kevin Ortner (VK)

Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, 2400 Copenhagen, Denmark.

Merete Haedersdal (M)

Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, 2400 Copenhagen, Denmark.

Uffe Høgh Olesen (UH)

Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, 2400 Copenhagen, Denmark.

Classifications MeSH