Synthesis of Celecoxib-Eutectic Mixture Particles via Supercritical CO
adipic acid
celecoxib
eutectic mixture
quality by design
saccharin
spray drying
supercritical fluid
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
26 Jul 2022
26 Jul 2022
Historique:
received:
30
05
2022
revised:
15
07
2022
accepted:
18
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Significant improvements in the wettability and dissolution rate of celecoxib (CEL), a poorly soluble selective cyclooxygenase-2 (COX-2) inhibitor, have been shown by Huyn et al., 2019 by combining the binary pharmaceutical compositions including CEL and one of the two co-formers, adipic acid (ADI) and saccharin (SAC), into eutectic mixtures (EM).
Identifiants
pubmed: 35893805
pii: pharmaceutics14081549
doi: 10.3390/pharmaceutics14081549
pmc: PMC9331714
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2021R1A2C2008834
Organisme : National Research Foundation of Korea
ID : 2018R1A6A1A03023718
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