Anti-TNFα Treatment Impairs Long-Term Immune Responses to COVID-19 mRNA Vaccine in Patients with Inflammatory Bowel Diseases.
COVID-19
anti-SARS-CoV-2 antibodies
circulating B cells
cross-reactivity
mRNA-BNT162b2
serologic response longevity
vaccine
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
26 Jul 2022
26 Jul 2022
Historique:
received:
19
06
2022
revised:
20
07
2022
accepted:
21
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Patients with inflammatory bowel disease (IBD) treated with anti-tumor-necrosis factor-alpha (TNFα) exhibited lower serologic responses one-month following the second dose of the COVID-19 BNT162b2 vaccine compared to those not treated with anti-TNFα (non-anti-TNFα) or to healthy controls (HCs). We comprehensively analyzed long-term humoral responses, including anti-spike (S) antibodies, serum inhibition, neutralization, cross-reactivity and circulating B cell six months post BNT162b2, in patients with IBD stratified by therapy compared to HCs. Subjects enrolled in a prospective, controlled, multi-center Israeli study received two BNT162b2 doses. Anti-S levels, functional activity, specific B cells, antigen cross-reactivity, anti-nucleocapsid levels, adverse events and IBD disease score were detected longitudinally. In total, 240 subjects, 151 with IBD (94 not treated with anti-TNFα and 57 treated with anti-TNFα) and 89 HCs participated. Six months after vaccination, patients with IBD treated with anti-TNFα had significantly impaired BNT162b2 responses, specifically, more seronegativity, decreased specific circulating B cells and cross-reactivity compared to patients untreated with anti-TNFα. Importantly, all seronegative subjects were patients with IBD; of those, >90% were treated with anti-TNFα. Finally, IBD activity was unaffected by BNT162b2. Altogether these data support the earlier booster dose administration in these patients.
Identifiants
pubmed: 35893835
pii: vaccines10081186
doi: 10.3390/vaccines10081186
pmc: PMC9330864
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Israel Science Foundation
ID : 1422/18
Organisme : Israel Science Foundation
ID : 3711/20
Organisme : Israel Science Foundation
ID : 2475/19
Organisme : Israel Science Foundation
ID : 401/18
Organisme : Leona M. and Harry B. Helmsley Charitable Trust
ID : G-2101-04950
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