Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials.


Journal

Journal of internal medicine
ISSN: 1365-2796
Titre abrégé: J Intern Med
Pays: England
ID NLM: 8904841

Informations de publication

Date de publication:
12 2022
Historique:
pubmed: 28 7 2022
medline: 10 11 2022
entrez: 27 7 2022
Statut: ppublish

Résumé

Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4). To determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibodies. We pooled individual participant data from two RCTs, Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism and IEMO 80+. Participants with persistent SHypo were randomly assigned to receive LT4 or placebo. We compared the effects of LT4 versus placebo in participants with and without anti-thyroid peroxidase (TPO) at baseline. The two primary outcomes were 1-year change in Hypothyroid Symptoms and Tiredness scores on the Thyroid-Related Quality-of-Life Patient-Reported Outcome Questionnaire. Among 660 participants (54% women) ≥65 years, 188 (28.5%) had positive anti-TPO. LT4 versus placebo on Hypothyroid Symptoms lead to an adjusted between-group difference of -2.07 (95% confidence interval: -6.04 to 1.90) for positive antibodies versus 0.89 (-1.76 to 3.54) for negative antibodies (p for interaction = 0.31). Similarly, there was no treatment effect modification by baseline antibody status for Tiredness scores-adjusted between-group difference 1.75 (-3.60 to 7.09) for positive antibodies versus 1.14 (-1.90 to 4.19) for negative antibodies (p for interaction = 0.98). Positive anti-TPO were not associated with better quality of life, improvement in handgrip strength, or fewer cardiovascular outcomes with levothyroxine treatment. Among older adults with SHypo, positive antithyroid antibodies are not associated with more benefits on clinical outcomes with LT4.

Sections du résumé

BACKGROUND
Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4).
OBJECTIVE
To determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibodies.
METHODS
We pooled individual participant data from two RCTs, Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism and IEMO 80+. Participants with persistent SHypo were randomly assigned to receive LT4 or placebo. We compared the effects of LT4 versus placebo in participants with and without anti-thyroid peroxidase (TPO) at baseline. The two primary outcomes were 1-year change in Hypothyroid Symptoms and Tiredness scores on the Thyroid-Related Quality-of-Life Patient-Reported Outcome Questionnaire.
RESULTS
Among 660 participants (54% women) ≥65 years, 188 (28.5%) had positive anti-TPO. LT4 versus placebo on Hypothyroid Symptoms lead to an adjusted between-group difference of -2.07 (95% confidence interval: -6.04 to 1.90) for positive antibodies versus 0.89 (-1.76 to 3.54) for negative antibodies (p for interaction = 0.31). Similarly, there was no treatment effect modification by baseline antibody status for Tiredness scores-adjusted between-group difference 1.75 (-3.60 to 7.09) for positive antibodies versus 1.14 (-1.90 to 4.19) for negative antibodies (p for interaction = 0.98). Positive anti-TPO were not associated with better quality of life, improvement in handgrip strength, or fewer cardiovascular outcomes with levothyroxine treatment.
CONCLUSIONS
Among older adults with SHypo, positive antithyroid antibodies are not associated with more benefits on clinical outcomes with LT4.

Identifiants

pubmed: 35894851
doi: 10.1111/joim.13544
pmc: PMC9796496
doi:

Substances chimiques

Thyroxine Q51BO43MG4

Types de publication

Meta-Analysis Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

892-903

Informations de copyright

© 2022 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.

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Auteurs

Christina Lyko (C)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.

Manuel R Blum (MR)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Nazanin Abolhassani (N)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.

Mirah J Stuber (MJ)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Cinzia Del Giovane (C)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.

Martin Feller (M)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.

Elisavet Moutzouri (E)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.

Jolanda Oberle (J)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Katharina T Jungo (KT)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.

Tinh-Hai Collet (TH)

Service of Endocrinology, Diabetes, Nutrition and Therapeutic Education, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.

Wendy P J den Elzen (WPJ)

Atalmedial Diagnostics Centre, Amsterdam, The Netherlands.
Amsterdam UMC, Department of Clinical Chemistry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Rosalinde K E Poortvliet (RKE)

Department of Public Health and Primary Care, Leiden University Medical Center UMC, Leiden, The Netherlands.

Robert S Du Puy (RS)

Department of Public Health and Primary Care, Leiden University Medical Center UMC, Leiden, The Netherlands.

Olaf M Dekkers (OM)

Department of Endocrinology and Metabolic Disorders, Leiden University Medical Center, Leiden, The Netherlands.

Stella Trompet (S)

Department of Internal Medicine-Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

J Wouter Jukema (JW)

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Netherlands Heart Institute, Utrecht, The Netherlands.

Drahomir Aujesky (D)

Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Terry Quinn (T)

Academic Section of Geriatric Medicine, Institute of Cardiovascular and Medical Sciences University of Glasgow, Glasgow, UK.

Rudi Westendorp (R)

Department of Public Health and, Center for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark.

Patricia M Kearney (PM)

Department of Epidemiology and Public Health, University College Cork, Cork, Ireland.

Jacobijn Gussekloo (J)

Department of Public Health and Primary Care, Leiden University Medical Center UMC, Leiden, The Netherlands.

Diana Van Heemst (D)

Department of Internal Medicine-Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

Simon P Mooijaart (SP)

Department of Internal Medicine-Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

Douglas C Bauer (DC)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Department of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, USA.

Nicolas Rodondi (N)

Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

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