Gender Moderates Results of a Randomized Clinical Trial for the Khanya Intervention for Substance Use and ART Adherence in HIV Care in South Africa.
ART adherence
Behavioral intervention
Gender differences
South Africa
Substance use
Journal
AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
accepted:
04
04
2022
pubmed:
28
7
2022
medline:
13
10
2022
entrez:
27
7
2022
Statut:
ppublish
Résumé
Little is known about gender effects of alcohol and drug use (AOD) among people living with HIV (PLWH) in resource-limited settings. Using multilevel models, we tested whether gender moderated the effect of Khanya, a cognitive-behavioral therapy-based intervention addressing antiretroviral (ART) adherence and AOD reduction. We enrolled 61 participants from HIV care and examined outcomes at 3- and 6-months compared to enhanced treatment as usual (ETAU). Gender significantly moderated the effect of Khanya on ART adherence (measured using electronically-monitored and biomarker-confirmed adherence), such that women in Khanya had significantly lower ART adherence compared to men in Khanya; no gender differences were found for AOD outcomes. Exploratory trajectory analyses showed men in Khanya and both genders in ETAU had significant reductions in at least one AOD outcome; women in Khanya did not. More research is needed to understand whether a gender lens can support behavioral interventions for PLWH with AOD.Trial registry ClinicalTrials.gov identifier: NCT03529409. Trial registered on May 18, 2018.
Identifiants
pubmed: 35895150
doi: 10.1007/s10461-022-03765-8
pii: 10.1007/s10461-022-03765-8
pmc: PMC9550692
doi:
Substances chimiques
Anti-Retroviral Agents
0
Banques de données
ClinicalTrials.gov
['NCT03529409']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
3630-3641Subventions
Organisme : NIMH NIH HHS
ID : P30 MH116867
Pays : United States
Organisme : NIDA NIH HHS
ID : K24 DA040489
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24 AA022586
Pays : United States
Organisme : NIMH NIH HHS
ID : F31 MH123020
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH103770
Pays : United States
Informations de copyright
© 2022. The Author(s).
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