Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry.

Humans Severity of Illness Index Treatment Outcome Antibodies, Monoclonal, Humanized / adverse effects Registries

Journal

The British journal of dermatology
ISSN: 1365-2133
Titre abrégé: Br J Dermatol
Pays: England
ID NLM: 0004041

Informations de publication

Date de publication:
12 2022
Historique:
revised: 22 07 2022
received: 24 05 2022
accepted: 22 07 2022
pubmed: 28 7 2022
medline: 7 12 2022
entrez: 27 7 2022
Statut: ppublish

Résumé

This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term efficacy, favourable safety and high persistence of dupilumab under real life conditions.

Identifiants

DOI: 10.1111/bjd.21794 PMID: 35895855
pubmed: 35895855
doi: 10.1111/bjd.21794
doi:

Substances chimiques

dupilumab 420K487FSG
Antibodies, Monoclonal, Humanized 0

Types de publication

Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

1022-1024

Subventions

Organisme : TREATgermany is an academia-led, investigator-initiated clinical registry that is financially supported by AbbVie GmbH & Co KG, Galderma SA, LEO Pharma GmbH, Lilly Deutschland GmbH, Pfizer Inc. and Sanofi Deutschland GmbH.

Informations de copyright

© 2022 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.

Références

Simpson EL, Bieber T, Guttman-Yassky E et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med 2016; 375:2335-48.
Ratchataswan T, Banzon TM, Thyssen JP et al. Biologics for treatment of atopic dermatitis: current status and future prospect. J Allergy Clin Immunol Pract 2021; 9:1053-65.
Stölzl D, Weidinger S, Drerup K. A new era has begun: treatment of atopic dermatitis with biologics. Allergol Select 2021; 5:265-73.
Drucker AM, Morra DE, Prieto-Merino D et al. Systemic immunomodulatory treatments for atopic dermatitis: update of a living systematic review and network meta-analysis. JAMA Dermatol 2022; 158:523-32.
Schmitt J, Abraham S, Trautmann F et al. Usage and effectiveness of systemic treatments in adults with severe atopic eczema: first results of the German Atopic Eczema Registry TREATgermany. J Dtsch Dermatol Ges 2017; 15:49-59.
Heratizadeh A, Haufe E, Stölzl D et al. Baseline characteristics, disease severity and treatment history of patients with atopic dermatitis included in the German AD Registry TREATgermany. J Eur Acad Dermatol Venereol 2020; 34:1263-72.
Spekhorst LS, Ariëns LFM, van der Schaft J et al. Two-year drug survival of dupilumab in a large cohort of difficult-to-treat adult atopic dermatitis patients compared to cyclosporine A and methotrexate: results from the BioDay registry. Allergy 2020; 75:2376-9.

Auteurs

Dora Stölzl (D)

Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
ORCID: 0000-0001-7321-7305

Nicole Sander (N)

Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Annice Heratizadeh (A)

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
ORCID: 0000-0002-9231-9865

Eva Haufe (E)

Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.

Inken Harder (I)

Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Susanne Abraham (S)

Department of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, TU Dresden, Germany.
ORCID: 0000-0001-7457-6481

Luise Heinrich (L)

Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.

Andreas Kleinheinz (A)

Clinics for Dermatology, Elbe Klinikum Buxtehude, Germany.

Andreas Wollenberg (A)

Clinics and Outpatient Clinics for Dermatology and Allergy, LMU Munich, Germany.

Elke Weisshaar (E)

Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University Heidelberg, Germany.

Knut Schäkel (K)

Department of Dermatology, Ruprecht-Karls University Heidelberg, Germany.
ORCID: 0000-0001-6344-7799

Konstantin Ertner (K)

Practice Dr. med. Konstantin Ertner, Nürnberg, Germany.

Franca Wiemers (F)

Practice Dr. med. Franca Wiemers, Leipzig, Germany.

Julia Wildberger (J)

Practice Dr. med. Julia Wildberger, Hautmedizin, Bad Soden, Germany.

Margitta Worm (M)

Clinics for Dermatology, Venerology and Allergy, Charité Berlin, Germany.
ORCID: 0000-0002-3449-1245

Ralph von Kiedrowski (R)

CMSS - Company for Medical Study and Service, Selters, Westerwald, Germany.

Isaak Effendy (I)

Department of Dermatology, Hospital Rosenhoehe, Bielefeld, Germany.

Andrea Asmussen (A)

Practice Dr. med. Andrea Asmussen, Dermatology at Lesum, Bremen, Germany.

Matthias Augustin (M)

Institute for Health Services Research in Dermatology Hamburg, University Medical Center Hamburg-Eppendorf, Germany.
ORCID: 0000-0002-4026-8728

Mario Pawlak (M)

Practice Dr. med. Anika Hünermund and Mario Pawlak, Heilbad Heiligenstadt, Germany.

Michael Sticherling (M)

Department of Dermatology, University Hospital, Friedrich-Alexander-University Erlangen-Nuernberg, Germany.
ORCID: 0000-0001-9396-3938

Alexander Zink (A)

Department of Dermatology and Allergy, School of Medicine, Technical University of Munich and Clinical Unit Allergology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Germany.
ORCID: 0000-0001-9313-6588

Melanie Hilgers (M)

Clinics for Dermatology and Allergy, University Hospital Aachen, Germany.

Christiane Handrick (C)

Practice Dr. med. Christiane Handrick, Berlin, Germany.

Sven Quist (S)

Dermatology Clinic, Helix Medical Excellence Center Mainz, Germany.

Beate Schwarz (B)

Practice Dr. med. Beate Schwarz, Langenau, Germany.

Petra Staubach-Renz (P)

Department of Dermatology and Allergy, University Medical Center Mainz, Germany.

Magnus Bell (M)

Practice Dr. med. Magnus Bell, Thomas Kaiser, Andernach, Germany.

Sun-Hei Hong-Weldemann (SH)

Practice Dr. med. Sun-Hei Hong-Weldemann, Freiburg, Germany.

Bernhard Homey (B)

Department of Dermatology, Heinrich-Heine-University Duesseldorf, Germany.

Jens-Joachim Brücher (JJ)

Hautambulatorium Magdeburg, Germany.

Jochen Schmitt (J)

Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.

Thomas Werfel (T)

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

Stephan Weidinger (S)

Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
ORCID: 0000-0003-3944-252X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Real-world data on the effectiveness, safety...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Real-world data on the effectiveness, safety...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Real-world data on the effectiveness, safety...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Real-world data on the effectiveness, safety...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enregistrements › Real-world data on the effectiveness, safety...