Palmitate Potentiates Lipopolysaccharide-Induced IL-6 Production via Coordinated Acetylation of H3K9/H3K18, p300, and RNA Polymerase II.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 08 2022
15 08 2022
Historique:
received:
24
09
2021
accepted:
08
06
2022
pubmed:
28
7
2022
medline:
17
8
2022
entrez:
27
7
2022
Statut:
ppublish
Résumé
IL-6 is elevated in obese individuals and participates in the metabolic dysfunction associated with that condition. However, the mechanisms that promote IL-6 expression in obesity are incompletely understood. Because elevated levels of palmitate and LPS have been reported in obesity, we investigated whether these agents interact to potentiate IL-6 production. In this study, we report that LPS induces higher levels of IL-6 in human monocytes in the presence of palmitate. Notably, the priming effect of palmitate is associated with enhanced p300 binding and transcription factor recruitment to
Identifiants
pubmed: 35896337
pii: jimmunol.2100928
doi: 10.4049/jimmunol.2100928
doi:
Substances chimiques
Histones
0
Interleukin-6
0
Lipopolysaccharides
0
Palmitates
0
RNA Polymerase II
EC 2.7.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
731-741Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.